|
Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Brekke OL, Christiansen D, Lambris JD, Mollnes TE.
(2010).
Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood.
Molecular immunology
47: 1774-82
.
|
|
|
|
|
Danielsson A, Elgue G, Nilsson BM, Nilsson B, Lambris JD, Tötterman TH, Kochanek S, Kreppel F, Essand M.
(2010).
An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood.
Gene therapy
:.
|
|
|
|
|
Deak E, Jayakumar A, Cho KW, Goldsmith-Pestana K, Dondji B, Lambris JD, McMahon-Pratt D.
(2010).
Murine visceral leishmaniasis: IgM and polyclonal B-cell activation lead to disease exacerbation.
European Journal of Immunology
40: 1355-68
.
|
|
|
|
|
Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, Lambris JD, Geisbrecht BV.
(2010).
Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
Journal of Molecular Biology
:
.
|
|
|
|
|
Grasis JA, Guimond DM, Cam NR, Herman K, Magotti P, Lambris JD, Tsoukas CD.
(2010).
In vivo significance of ITK-SLP-76 interaction in cytokine production.
Molecular and cellular biology
30: 3596-609
.
|
|
|
|
|
Hamad OA, Nilsson PH, Wouters D, Lambris JD, Ekdahl KN, Nilsson B.
(2010).
Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1.
Journal of Immunology
184: 2686-92.
|
|
|
|
|
Haspel N, Geisbrecht BV, Lambris JD, Kavraki L.
(2010).
Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex.
Proteins
78: 1004-14.
|
|
|
|
|
Kourtzelis I, Markiewski MM, Doumas M, Rafail S, Kambas K, Mitroulis I, Panagoutsos S, Passadakis P, Vargemezis V, Magotti P, Qu H, Mollnes TE, Ritis K, Lambris JD.
(2010).
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis.
Blood
:
.
|
|
|
|
|
Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, Deangelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD*, Chavakis T*.
(2010).
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis..
Blood
: *Shared supervision
.
|
|
|
|
|
Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Sfyroera G, Magotti P, Ivanciu L, Lupu C, Mollnes TE, Taylor FB, Kinasewitz G, Lambris JD*, Lupu F*.
(2010).
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of E. coli sepsis.
Blood
: * Shared supervision
.
|
|
|
|
|
Wang M, Krauss JL, Domon H, Hosur KB, Liang S, Magotti P, Triantafilou M, Triantafilou K, Lambris JD, Hajishengallis G.
(2010).
Microbial hijacking of complement-toll-like receptor crosstalk.
Science Signaling
16;3(109):ra11
.
Additional Links:
Podcast,
Perspectives,
Supplementary Information.
|
|
|
|
|
Garcia BL, Tzekou A, Ramyar KX, McWhorter WJ, Ricklin D, Lambris JD, Geisbrecht BV.
(2009).
Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN).
Acta crystallographica. Section F, Structural biology and crystallization communications
65: 482-5.
|
|
|
|
|
Georgopoulos LJ, Elgue G, Sanchez J, Dussupt V, Magotti P, Lambris JD, Tötterman TH, Maitland NJ, Nilsson B.
(2009).
Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood.
Molecular immunology
46: 2911-7.
|
|
|
|
|
Lappegård KK, Christiansen DD, Pharo AA, Thorgersen EE, Hellerud BB, Lindstad JJ, Nielsen EE, Bergseth GG, Fadnes DD, Abrahamsen TT, Høiby EE, Schejbel LL, Garred PP, Lambris JD, Harboe MM, Mollnes TT.
(2009).
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature.
Proceedings of the National Academy of Sciences of the United States of America
106: 15861-6
.
|
|
|
|
|
Magotti P, Ricklin D, Qu H, Wu YQ, Kaznessis YN, Lambris JD.
(2009).
Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin..
Journal of Molecular Recognition
22: 495-505
.
|
|
|
|
|
Mangsbo SM, Sanchez J, Anger K, Lambris JD, Ekdahl KN, Loskog AS, Nilsson B, Totterman TH.
(2009).
Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects.
J Immunol
183:6724-32.
Additional Links:
Supplementary Information.
|
|
|
|
|
Nakayama Y, Kim SI, Kim EH, Lambris JD, Sandor M, Suresh M.
(2009).
C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection.
Journal of Immunology
183: 2921-31
.
|
|
|
|
|
Ricklin D, Tzekou A, Garcia BL, Hammel M, McWhorter WJ, Sfyroera G, Wu YQ, Holers VM, Herbert AP, Barlow PN, Geisbrecht BV, Lambris JD.
(2009).
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family..
Journal of Immunology
183: 2565-74
.
|
|
|
|
|
Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P.
(2009).
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Nature immunology
10: 721-7.
Additional Links:
Supplementary Information.
|
|
|
|
|
Thorgersen EB, Ludviksen JK, Lambris JD, Sfyroera G, Nielsen EW, Mollnes TE.
(2009).
Anti-inflammatory effects of c1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity.
Innate Immunity
:
.
|
|
|
|
|
Wu J, Wu YQ, Ricklin D, Janssen BJ, Gros P, Lambris JD.
(2009).
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
Nature Immunology
10: 728-33.
Additional Links:
Supplementary Information.
|
|
|
|
|
Chen H, Schuster MC, Sfyroera G, Geisbrecht BV, Lambris JD.
(2008).
Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry.
Journal of the American Society for Mass Spectrometry
19: 55-65.
|
|
|
|
|
Chiu TL, Mulakala C, Lambris JD, Kaznessis YN.
(2008).
Development of a new pharmacophore model that discriminates active compstatin analogs.
Chemical Biology & Drug Design
72: 249-56
.
|
|
|
|
|
Fleming SD, Phillips LM, Lambris JD.
(2008).
Complement component C5a mediates hemorrhage-induced intestinal damage.
J Surg Res
150:196-203.
|
|
|
|
|
Goto M, Tjernberg J, Dufrane D, Elgue G, Brandhorst D, Ekdahl KN, Brandhorst H, Wennberg L, Kurokawa Y, Satomi S, Lambris JD, Gianello P, Korsgren O, Nilsson B.
(2008).
Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation.
Xenotransplantation
15: 225-34
.
|
|
|
|
|
Hadziahmetovic M, Dentchev T, Song Y, Haddad N, He XN, Hahn P, Pratico D, Wen R, Harris ZL, Lambris JD, Beard J, Dunaief JL.
(2008).
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.
Investigative Ophthalmology & Visual Science
49 (6):2728-2736.
|
|
|
|
|
Hamad OA, Eldahi KN, Nilsson PH, Andersson J, Magotti P, Lambris JD, Nilsson B.
(2008).
Complement activation triggered by chondroitin sulfare released by thrombin receptoractivated platelets.
Journal of Thromb Haemost
6 (8):1413-1421.
|
|
|
|
|
Haspel N, Ricklin D, Geisbrecht BV, Kavraki LE, Lambris JD.
(2008).
Electrostatic Contributions Drive the Interaction Between Staphylococcus aureus Protein Efb-C and its Complement Target C3d.
Protein Science
17:1894-1906.
Additional Links:
Supplementary Material.
|
|
|
|
|
Hellerud BC, Stenvik J, Espevik T, Lambris JD, Mollnes TE, Brandtzaeg P.
(2008).
Stages of meningococcal sepsis simulated in vitro, with emphasis on complement and Toll-like receptor activation.
Infection and Immunity
76: 4183-9
.
|
|
|
|
|
Kambas K, Markiewski MM, Pneumatikos IA, Rafail S, Theodorou V, Konstantonis D, Kourtzelis I, Doumas MN, Magotti P, DeAngelis RA, Lambris JD*, Ritis KD*.
(2008).
C5a and TNF-{alpha} up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrom.
Journal of Immunology
180:7368-7375. *co-supervised this work.
|
|
|
|
|
Lappegård KT, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris JD, Mollnes TE.
(2008).
The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent.
Journal of Biomedical Materials Research. Part A
87: 129-35
.
|
|
|
|
|
Markiewski MM, DeAngelis RA, Benencia F, Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, Coukos G, Lambris JD.
(2008).
Modulation of the anti-tumor immune response by complement.
Nature Immunology
9 (11):1225-1235.
Additional Links:
Nature Biotechnology News & Views,
Nature Cancer Reviews Highlight,
Nature Immunology News & Views,
Supplementary Information.
|
|
|
|
|
Ricklin D, Ricklin-Lichtsteiner SK, Markiewski MM, Geisbrecht BV, Lambris JD.
(2008).
Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2.
Journal of Immunology
181: 7463-7
.
|
|
|
|
|
Rynkowski MA, Kim GH, Garrett MC, Zacharia BE, Otten ML, Sosunov SA, Komotar RJ, Hassid BG, Ducruet AF, Lambris JD, Connolly ES.
(2008).
C3a receptor antagonist attenuates brain injury after intracerebral hemorrhage.
Journal of Cerebral Blood Flow and Metabolism
29: 98-107
.
|
|
|
|
|
Saethre M, Schneider MK, Lambris JD, Magotti P, Haraldsen G, Seebach JD, Mollnes TE.
(2008).
Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model..
Journal of Immunology
180: 6346-53
.
|
|
|
|
|
Schuster MC, Ricklin D, Papp K, Molnar KS, Coales SJ, Hamuro Y, Sfyroera G, Chen H, Winters MS, Lambris JD.
(2008).
Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry.
Molecular Immunology
45: 3142-51
.
|
|
|
|
|
Tjernberg J, Ekdahl KN, Lambris JD, Korsgren O, Nilsson B.
(2008).
Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation.
Transplantation
85: 1193-9
.
|
|
|
|
|
Zucchetti I, Marino R, Pinto MR, Lambris JD, Du Pasquier L, De Santis R.
(2008).
ciCD94-1, an ascidian multipurpose C-type lectin-like receptor expressed in Ciona intestinalis hemocytes and larval neural structures.
Differentiation
76: 267-82
.
|
|
|
|
|
Hammel M, Sfyroera G, Pyrpassopoulos S, Ricklin D, Ramyar KX, Pop M, Jin Z, Lambris JD, Geisbrecht BV.
(2007).
Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus.
The Journal of Biological Chemistry
282: 30051-61
.
|
|
|
|
|
Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV.
(2007).
A structural basis for complement inhibition by Staphylococcus aureus.
Nature Immunology
8: 430-7
.
Additional Links:
Science Editor's Choice.
|
|
|
|
|
Janssen BJ, Halff EF, Lambris JD, Gros P.
(2007).
Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
The Journal of Biological Chemistry
282: 29241-7
.
Additional Links:
Supplementary Information.
|
|
|
|
|
Józsi M, Oppermann M, Lambris JD, Zipfel PF.
(2007).
The C-terminus of complement factor H is essential for host cell protection.
Molecular Immunology
44: 2697-706
.
|
|
|
|
|
Montalvo V, Campos MM, Chan CC, Wawrousek EF, Bush RA, Lambris JD, Gery I.
(2007).
Complement deposits on ocular tissues adjacent to sites of inflammation.
Current Eye Research
32: 917-22
.
|
|
|
|
|
Mulakala C, Lambris JD, Kaznessis Y.
(2007).
A simple, yet highly accurate, QSAR model captures the complement inhibitory activity of compstatin.
Bioorganic & Medicinal Chemistry
15: 1638-44
.
|
|
|
|
|
Pedersen ED, Aass HC, Rootwelt T, Fung M, Lambris JD, Mollnes TE.
(2007).
CD59 efficiently protects human NT2-N neurons against complement-mediated damage.
Scandinavian Journal of Immunology
66: 345-51
.
|
|
|
|
|
Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B, Sher A, Litke AM, Lambris JD, Smith SJ, John SW, Barres BA.
(2007).
The classical complement cascade mediates CNS synapse elimination.
Cell
131: 1164-78
.
Additional Links:
Cell Preview,
Science News of The Week.
|
|
|
|
|
Tamamis P, Skourtis SS, Morikis D, Lambris JD, Archontis G.
(2007).
Conformational analysis of compstatin analogues with molecular dynamics simulations in explicit water.
Journal of Molecular Graphics & Modeling
26: 571-80
.
|
|
|
|
|
Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM.
(2007).
C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion.
Journal of Immunology
178: 1819-28
.
|
|
|
|
|
Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris JD, Wetsel RA, Miwa T, Song WC.
(2007).
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo.
Blood
110: 228-36
.
|
|
|
|
|
Anderson AL, Sporici R, Lambris J, Larosa D, Levinson AI.
(2006).
Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation.
Infection and Immunity
74: 1196-203
.
|
|
|
|
|
Drouin SM, Sinha M, Sfyroera G, Lambris JD, Wetsel RA.
(2006).
A protective role for the fifth complement component (c5) in allergic airway disease..
American Journal of Respiratory and Critical Care Medicine
173: 852-7
.
|
|
|
|
|
Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA.
(2006).
Generation of C5a in the absence of C3: a new complement activation pathway.
Nature Medicine
12: 682-7
.
|
|
|
|
|
Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P.
(2006).
Structure of C3b reveals conformational changes that underlie complement activity.
Nature
444: 213-6
.
Additional Links:
News & Views.
|
|
|
|
|
Katragadda M, Lambris JD.
(2006).
Expression of compstatin in Escherichia coli: incorporation of unnatural amino acids enhances its activity..
Protein Expression and Purification
47: 289-95
.
|
|
|
|
|
Katragadda M, Magotti P, Sfyroera G, Lambris JD.
(2006).
Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin.
Journal of Medicinal Chemistry
49: 4616-22
.
|
|
|
|
|
Köhl J, Baelder R, Lewkowich IP, Pandey MK, Hawlisch H, Wang L, Best J, Herman NS, Sproles AA, Zwirner J, Whitsett JA, Gerard C, Sfyroera G, Lambris JD, Wills-Karp M.
(2006).
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma..
The Journal of Clinical Investigation
116: 783-96
.
|
|
|
|
|
Melillo D, Sfyroera G, De Santis R, Graziano R, Marino R, Lambris JD, Pinto MR.
(2006).
First identification of a chemotactic receptor in an invertebrate species: structural and functional characterization of Ciona intestinalis C3a receptor..
Journal of immunology (Baltimore, Md. : 1950)
177: 4132-40
.
|
|
|
|
|
Miwa T, Zhou L, Tudoran R, Lambris JD, Madaio MP, Nangaku M, Molina H, Song WC.
(2006).
DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity.
Molecular Immunology
44: 139-46
.
|
|
|
|
|
Nielsen EW, Waage C, Fure H, Brekke OL, Sfyroera G, Lambris JD, Mollnes TE.
(2006).
Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement.
Molecular Immunology
44: 1819-26
.
|
|
|
|
|
Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J.
(2006).
Drusen complement components C3a and C5a promote choroidal neovascularization.
Proceedings of the National Academy of Sciences of the United States of America
103: 2328-33
.
|
|
|
|
|
Ritis K, Doumas M, Mastellos D, Micheli A, Giaglis S, Magotti P, Rafail S, Kartalis G, Sideras P, Lambris JD.
(2006).
A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways..
Journal of Immunology
177: 4794-802.
|
|
|
|
|
Soulika AM, Holland MC, Sfyroera G, Sahu A, Lambris JD.
(2006).
Compstatin inhibits complement activation by binding to the beta-chain of complement factor 3.
Molecular Immunology
43: 2023-9
.
|
|
|
|
|
Bao L, Osawe I, Puri T, Lambris JD, Haas M, Quigg RJ.
(2005).
C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist.
European Journal of Immunology
35: 2496-506
.
|
|
|
|
|
DeAngelis RA, Markiewski MM, Taub R, Lambris JD.
(2005).
A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha..
Hepatology
42: 1148-57
.
|
|
|
|
|
Lappegård KT, Riesenfeld J, Brekke OL, Bergseth G, Lambris JD, Mollnes TE.
(2005).
Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production.
The Annals of Thoracic Surgery
79: 917-23
.
|
|
|
|
|
Li S, Boackle SA, Holers VM, Lambris JD, Blatteis CM.
(2005).
Complement component c5a is integral to the febrile response of mice to lipopolysaccharide..
Neuroimmunomodulation
12: 67-80
.
|
|
|
|
|
Liu J, Miwa T, Hilliard B, Chen Y, Lambris JD, Wells AD, Song WC.
(2005).
The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo.
The Journal of Experimental Medicine
201: 567-77
.
|
|
|
|
|
Mallik B, Katragadda M, Spruce LA, Carafides C, Tsokos CG, Morikis D, Lambris JD.
(2005).
Design and NMR characterization of active analogues of compstatin containing non-natural amino acids.
Journal of Medicinal Chemistry
48: 274-86
.
|
|
|
|
|
Pappas IS, Lambris JD, Vizirianakis IS, Winters MS, Tsiftsoglou AS.
(2005).
Mechanisms of action of differentiation inducers: detection of inducer binding protein(s) in murine erythroleukemia cells..
Oncology Research
15: 21-37
.
|
|
|
|
|
Sfyroera G, Katragadda M, Morikis D, Isaacs SN, Lambris JD.
(2005).
Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins.
Journal of Immunology
174: 2143-51
.
|
|
|
|
|
Strey CW, Winters MS, Markiewski MM, Lambris JD.
(2005).
Partial hepatectomy induced liver proteome changes in mice.
Proteomics
5: 318-25
.
|
|
|
|
|
Winters MS, Spellman DS, Lambris JD.
(2005).
Solvent accessibility of native and hydrolyzed human complement protein 3 analyzed by hydrogen/deuterium exchange and mass spectrometry.
Journal of Immunology
174: 3469-74
.
|
|
|
|
|
Andersson J, Ekdahl KN, Lambris JD, Nilsson B.
(2004).
Binding of C3 fragments on top of adsorbed plasma proteins during complement activation on a model biomaterial surface.
Biomaterials
26: 1477-85
.
|
|
|
|
|
Bell E, Shamim M, Whitbeck JC, Sfyroera G, Lambris JD, Isaacs SN.
(2004).
Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin.
Virology
325: 425-31
.
|
|
|
|
|
Katragadda M, Morikis D, Lambris JD.
(2004).
Thermodynamic studies on the interaction of the third complement component and its inhibitor, compstatin.
The Journal of Biological Chemistry
279: 54987-95
.
|
|
|
|
|
Kim AH, Dimitriou ID, Holland MC, Mastellos D, Mueller YM, Altman JD, Lambris JD, Katsikis PD.
(2004).
Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses..
Journal of Immunology
173: 2524-9
.
|
|
|
|
|
Klepeis JL, Floudas CA, Morikis D, Tsokos CG, Lambris JD.
(2004).
Design of peptide analogues with improves activity using a novel de Novo protein design approach.
Industrial & Engineering Chemistry Research
43 (14):3817-3826
.
|
|
|
|
Lappegård KT, Fung M, Bergseth G, Riesenfeld J, Lambris JD, Videm V, Mollnes TE.
(2004).
Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation.
The Annals of Thoracic Surgery
77: 932-41
.
|
|
|
|
|
Markiewski MM, Mastellos D, Tudoran R, DeAngelis RA, Strey CW, Franchini S, Wetsel RA, Erdei A, Lambris JD.
(2004).
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury.
Journal of Immunology
173: 747-54
.
|
|
|
|
|
Mastellos D, Prechl J, László G, Papp K, Oláh E, Argyropoulos E, Franchini S, Tudoran R, Markiewski M, Lambris JD Erdei A.
(2004).
Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays.
Molecular Immunology
40: 1213-21
.
|
|
|
|
|
Morikis D, Lambris JD.
(2004).
The electrostatic nature of C3d-complement receptor 2 association..
Journal of Immunology
172: 7537-47
.
|
|
|
|
|
Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Shultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW.
(2004).
Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.
American Journal of Respiratory and Critical Care Medicine
169: 726-32
.
|
|
|
|
|
Sewell DL, Nacewicz B, Liu F, Macvilay S, Erdei A, Lambris JD, Sandor M, Fabry Z.
(2004).
Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist.
Journal of Neuroimmunology
155: 55-63
.
|
|
|
|
|
Strey CW, Spellman D, Stieber A, Gonatas JO, Wang X, Lambris JD, Gonatas NK.
(2004).
Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis.
The American Journal of Pathology
165: 1701-18
.
|
|
|
|
|
Fleming SD, Mastellos D, Karpel-Massler G, Shea-Donohue T, Lambris JD, Tsokos GC.
(2003).
C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury.
Clinical Immunology
108: 263-73
.
|
|
|
|
|
Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE.
(2003).
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.
The Journal of Clinical Investigation
112: 1644-54
.
Additional Links:
Erratum.
|
|
|
|
|
Holland MC, Lambris JD.
(2003).
A functional C5a anaphylatoxin receptor in a teleost species.
Journal of Immunology
172: 349-55
.
|
|
|
|
|
Isaacs SN, Argyropoulos E, Sfyroera G, Mohammad S, Lambris JD.
(2003).
Restoration of complement-enhanced neutralization of vaccinia virus virions by novel monoclonal antibodies raised against the vaccinia virus complement control protein.
Journal of Virology
77: 8256-62
.
|
|
|
|
|
Kazantzi A, Sfyroera G, Holland MC, Lambris JD, Zarkadis IK.
(2003).
Molecular cloning of the beta subunit of complement component eight of rainbow trout.
Developmental and Comparative Immunology
27: 167-74
.
|
|
|
|
|
Kimura Y, Madhavan M, Call MK, Santiago W, Tsonis PA, Lambris JD, Del Rio-Tsonis K.
(2003).
Expression of complement 3 and complement 5 in newt limb and lens regeneration.
Journal of Immunology
170: 2331-9
.
Additional Links:
In This Issue.
|
|
|
|
|
Klepeis JL, Floudas CA, Morikis D, Tsokos CG, Argyropoulos E, Spruce L, Lambris JD.
(2003).
Integrated computational and experimental approach for lead optimization and design of compstatin variants with improved activity.
Journal of the American Chemical Society
125: 8422-3
.
Additional Links:
Supplementary Information.
|
|
|
|
|
Mallik B, Lambris JD, Morikis D.
(2003).
Conformational interconversion in compstatin probed with molecular dynamics simulations.
Proteins
53: 130-41
.
|
|
|
|
|
Mullick J, Bernet J, Singh AK, Lambris JD, Sahu A.
(2003).
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) open reading frame 4 protein (kaposica) is a functional homolog of complement control proteins..
Journal of Virology
77: 3878-81
.
|
|
|
|
|
Pinto MR, Chinnici CM, Kimura Y, Melillo D, Marino R, Spruce LA, De Santis R, Parrinello N, Lambris JD.
(2003).
CiC3-1a-mediated chemotaxis in the deuterostome invertebrate Ciona intestinalis (Urochordata).
Journal of Immunology
171: 5521-8
.
|
|
|
|
|
Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S, Glodek A, Honczarenko M, Spruce LA, Janowska-Wieczorek A, Lambris JD, Ratajczak MZ.
(2003).
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1.
Blood
101: 3784-93
.
|
|
|
|
|
Soulika AM, Morikis D, Sarrias MR, Roy M, Spruce LA, Sahu A, Lambris JD.
(2003).
Studies of structure-activity relations of complement inhibitor compstatin.
Journal of Immunology
171: 1881-90
.
|
|
|
|
|
Strey CW, Markiewski M, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE, Lambris JD.
(2003).
The proinflammatory mediators C3a and C5a are essential for liver regeneration.
The Journal of Experimental Medicine
198: 913-23
.
|
|
|
|
|
Suresh M, Molina H, Salvato MS, Mastellos D, Lambris JD, Sandor M.
(2003).
Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection.
Journal of Immunology
170: 788-94
.
|
|
|
|
|
Barilla-LaBarca ML, Liszewski MK, Lambris JD, Hourcade D, Atkinson JP.
(2002).
Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells.
Journal of Immunology
168: 6298-304
.
|
|
|
|
|
Huber-Lang MS, Riedeman NC, Sarma JV, Younkin EM, McGuire SR, Laudes IJ, Lu KT, Guo RF, Neff TA, Padgaonkar VA, Lambris JD, Spruce L, Mastellos D, Zetoune FS, Ward PA.
(2002).
Protection of innate immunity by C5aR antagonist in septic mice.
The FASEB Journal
16: 1567-74
.
|
|
|
|
|
Laudes IJ, Chu JC, Huber-Lang M, Guo RF, Riedemann NC, Sarma JV, Mahdi F, Murphy HS, Speyer C, Lu KT, Lambris JD, Zetoune FS, Ward PA.
(2002).
Expression and function of C5a receptor in mouse microvascular endothelial cells.
Journal of Immunology
169: 5962-70
.
|
|
|
|
|
Lubinski JM, Jiang M, Hook L, Chang Y, Sarver C, Mastellos D, Lambris JD, Cohen GH, Eisenberg RJ, Friedman HM.
(2002).
Herpes simplex virus type 1 evades the effects of antibody and complement in vivo.
Journal of Virology
76: 9232-41
.
|
|
|
|
|
Marino R, Kimura Y, De Santis R, Lambris JD, Pinto MR.
(2002).
Complement in urochordates: cloning and characterization of two C3-like genes in the ascidian Ciona intestinalis.
Immunogenetics
53: 1055-64
.
|
|
|
|
|
Molina H, Miwa T, Zhou L, Hilliard B, Mastellos D, Maldonado MA, Lambris JD, Song WC.
(2002).
Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor..
Blood
100: 4544-9
.
|
|
|
|
|
Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappegård KT, Köhl J, Lambris JD.
(2002).
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation..
Blood
100: 1869-77
.
|
|
|
|
|
Morikis D, Roy M, Sahu A, Troganis A, Jennings PA, Tsokos GC, Lambris JD.
(2002).
The structural basis of compstatin activity examined by structure-function-based design of peptide analogs and NMR.
The Journal of Biological Chemistry
277: 14942-53
.
Additional Links:
Supplementary Information.
|
|
|
|
|
Riedemann NC, Guo RF, Neff TA, Laudes IJ, Keller KA, Sarma VJ, Markiewski MM, Mastellos D, Strey CW, Pierson CL, Lambris JD, Zetoune FS, Ward PA.
(2002).
Increased C5a receptor expression in sepsis.
The Journal of Clinical Investigation
110: 101-8
.
|
|
|
|
|
Riedemann NC, Neff TA, Guo RF, Bernacki KD, Laudes IJ, Sarma JV, Lambris JD, Ward PA.
(2002).
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression.
Journal of Immunology
170: 503-7
.
|
|
|
|
|
Rux AH, Lou H, Lambris JD, Friedman HM, Eisenberg RJ, Cohen GH.
(2002).
Kinetic analysis of glycoprotein C of herpes simplex virus types 1 and 2 binding to heparin, heparan sulfate, and complement component C3b.
Virology
294: 324-32
.
|
|
|
|
|
Sahu A, Morikis D, Lambris JD.
(2002).
Compstatin, a peptide inhibitor of complement, exhibits species-specific binding to complement component C3.
Molecular Immunology
39: 557-66
.
|
|
|
|
|
Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E.
(2002).
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice..
Proceedings of the National Academy of Sciences of the United States of America
99: 10837-42
.
|
|
|
|
|
Franchini S, Zarkadis IK, Sfyroera G, Sahu A, Moore WT, Mastellos D, LaPatra SE, Lambris JD.
(2001).
Cloning and purification of the rainbow trout fifth component of complement (C5).
Developmental and Comparative Immunology
25: 419-30
.
|
|
|
|
|
Guthridge JM, Rakstang JK, Young KA, Hinshelwood J, Aslam M, Robertson A, Gipson MG, Sarrias MR, Moore WT, Meagher M, Karp D, Lambris JD, Perkins SJ, Holers VM.
(2001).
Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg.
Biochemistry
40: 5931-41
.
|
|
|
|
|
Guthridge JM, Young K, Gipson MG, Sarrias MR, Szakonyi G, Chen XS, Malaspina A, Donoghue E, James JA, Lambris JD, Moir SA, Perkins SJ, Holers VM.
(2001).
Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface..
Journal of Immunology
167: 5758-66
.
|
|
|
|
|
Mastellos D, Papadimitriou JC, Franchini S, Tsonis PA, Lambris JD.
(2001).
A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration..
Journal of Immunology
166: 2479-86
.
|
|
|
|
|
Sarrias MR, Franchini S, Canziani G, Argyropoulos E, Moore WT, Sahu A, Lambris JD.
(2001).
Kinetic analysis of the interactions of complement receptor 2 (CR2, CD21) with its ligands C3d, iC3b, and the EBV glycoprotein gp350/220.
Journal of Immunology
167: 1490-9
.
Additional Links:
Biacore PDF.
|
|
|
|
|
Sarrias MR, Whitbeck JC, Rooney I, Ware CF, Eisenberg RJ, Cohen GH, Lambris JD.
(2001).
The three HveA receptor ligands, gD, LT-alpha and LIGHT bind to distinct sites on HveA.
Molecular Immunology
37: 665-73
.
|
|
|
|
|
Solvik,U.O., Haraldsen,G., Fiane,A.E., Boretti,E., Lambris,J.D., Fung,M., Thorsby,E. and Mollnes,T.E.
(2001).
Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated.
Transplantation
72 (12):1967-1973.
|
|
|
|
Vasta GR, Lambris JD.
(2001).
Innate immunity in the Aegean: ancient pathways for today's survival..
Developmental and Comparative Immunology
26: 217-25
.
|
|
|
|
|
Fiane AE, Videm V, Lambris JD, Geiran OR, Svennevig JL, Mollnes TE.
(2000).
Modulation of fluid-phase complement activation inhibits hyperacute rejection in a porcine-to-human xenograft model.
Transplantation Proceedings
32: 899-900
.
|
|
|
|
|
Friedman HM, Wang L, Pangburn MK, Lambris JD, Lubinski J.
(2000).
Novel mechanism of antibody-independent complement neutralization of herpes simplex virus type 1.
Journal of Immunology
165: 4528-36
.
|
|
|
|
|
Lubinski J, Wang L, Mastellos D, Sahu A, Lambris JD, Friedman HM.
(2000).
In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC.
The Journal of Experimental Medicine
190: 1637-46
.
|
|
|
|
|
Sahu A, Soulika AM, Morikis D, Spruce L, Moore WT, Lambris JD.
(2000).
Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin.
Journal of Immunology
165: 2491-9
.
|
|
|
|
|
Soulika AM, Khan MM, Hattori T, Bowen FW, Richardson BA, Hack CE, Sahu A, Edmunds LH, Lambris JD.
(2000).
Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons.
Clinical Immunology
96: 212-21
.
|
|
|
|
|
Zarkadis IK, Sarrias MR, Sfyroera G, Sunyer JO, Lambris JD.
(2000).
Cloning and structure of three rainbow trout C3 molecules: a plausible explanation for their functional diversity.
Developmental and Comparative Immunology
25: 11-24
.
|
|
|
|
|
Del Rio-Tsonis K, Tsonis PA, Zarkadis IK, Tsagas AG, Lambris JD.
(1999).
Expression of the third component of complement, C3, in regenerating limb blastema cells of urodeles.
Journal of Immunology
161: 6819-24
.
|
|
|
|
|
Fiane AE, Mollnes TE, Videm V, Hovig T, Høgåsen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD.
(1999).
Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts.
Xenotransplantation
6: 52-65
.
|
|
|
|
|
Fiane AE, Mollnes TE, Videm V, Hovig T, Høgåsen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD.
(1999).
Prolongation of ex vivo-perfused pig xenograft survival by the complement inhibitor Compstatin..
Transplantation Proceedings
31: 934-5
.
|
|
|
|
|
Klepeis JL, Floudas CA, Morikis D, Lambris JD.
(1999).
Predicting peptide structures using NMR data and deterministic global optimization.
Journal of Computational Chemistry
20:1354-1370
.
|
|
|
|
Lambris JD, Reid KB, Volanakis JE.
(1999).
The evolution, structure, biology and pathophysiology of complement.
Immunology Today
20: 207-11
.
|
|
|
|
|
Noorchashm H, Moore DJ, Lieu YK, Noorchashm N, Schlachterman A, Song HK, Lambris JD, Barker CF, Naji A.
(1999).
Contribution of the innate immune system to autoimmune diabetes: A role for the CR1/CR2 complement receptors.
Cellular Immunology
195:75-79
.
|
|
|
|
Sarrias MR, Whitbeck JC, Rooney I, Spruce L, Kay BK, Montgomery RI, Spear PG, Ware CF, Eisenberg RJ, Cohen GH, Lambris JD.
(1999).
Inhibition of herpes simplex virus gD and lymphotoxin-alpha binding to HveA by peptide antagonists.
Journal of Virology
73: 5681-7
.
|
|
|
|
|
Sun X, Funk CD, Deng C, Sahu A, Lambris JD, Song WC.
(1999).
Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting.
Proceedings of the National Academy of Sciences of the United States of America
96: 628-33
.
|
|
|
|
|
Al-Sharif WZ, Sunyer JO, Lambris JD, Smith LC.
(1998).
Sea urchin coelomocytes specifically express a homologue of the complement component C3.
Journal of Immunology
160: 2983-97
.
|
|
|
|
|
Krummenacher C, Nicola AV, Whitbeck JC, Lou H, Hou W, Lambris JD, Geraghty RJ, Spear PG, Cohen GH, Eisenberg RJ.
(1998).
Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry.
Journal of Virology
72: 7064-74
.
|
|
|
|
|
Lubinski JM, Wang L, Soulika AM, Burger R, Wetsel RA, Colten H, Cohen GH, Eisenberg RJ, Lambris JD, Friedman HM.
(1998).
Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo.
Journal of Virology
72: 8257-63
.
|
|
|
|
|
Morikis D, Assa-Munt N, Sahu A, Lambris JD.
(1998).
Solution structure of Compstatin, a potent complement inhibitor.
Protein Science
7: 619-27
.
|
|
|
|
|
Nilsson B, Larsson R, Hong J, Elgue G, Ekdahl KN, Sahu A, Lambris JD.
(1998).
Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulation.
Blood
92: 1661-7
.
|
|
|
|
|
Peng T, Ponce de Leon M, Novotny MJ, Jiang H, Lambris JD, Dubin G, Spear PG, Cohen GH, Eisenberg RJ.
(1998).
Structural and antigenic analysis of a truncated form of the herpes simplex virus glycoprotein gH-gL complex.
Journal of Virology
72: 6092-103
.
|
|
|
|
|
Sahu A, Isaacs SN, Soulika AM, Lambris JD.
(1998).
Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway..
Journal of Immunology
160: 5596-604
.
|
|
|
|
|
Sunyer JO, Zarkadis I, Sarrias MR, Hansen JD, Lambris JD.
(1998).
Cloning, structure, and function of two rainbow trout Bf molecules.
Journal of Immunology
161: 4106-14
.
|
|
|
|
|
Tolnay M, Lambris JD, Tsokos GC.
(1998).
Transcriptional regulation of the complement receptor 2 gene: role of a heterogeneous nuclear ribonucleoprotein..
Journal of Immunology
159: 5492-501
.
|
|
|
|
|
Kostavasili I, Sahu A, Friedman HM, Eisenberg RJ, Cohen GH, Lambris JD.
(1997).
Mechanism of complement inactivation by glycoprotein C of herpes simplex virus.
Journal of Immunology
158: 1763-71
.
|
|
|
|
|
Sunyer JO, Tort L, Lambris JD.
(1997).
Structural C3 diversity in fish: characterization of five forms of C3 in the diploid fish Sparus aurata..
Journal of immunology
158: 2813-21
.
|
|
|
|
|
Sunyer JO, Tort L, Lambris JD.
(1997).
Diversity of the third form of complement, C3, in fish: functional characterization of five forms of C3 in the diploid fish Sparus aurata..
The Biochemical Journal
326 ( Pt 3): 877-81
.
|
|
|
|
|
Whitbeck JC, Peng C, Lou H, Xu R, Willis SH, Ponce de Leon M, Peng T, Nicola AV, Montgomery RI, Warner MS, Soulika AM, Spruce LA, Moore WT, Lambris JD, Spear PG, Cohen GH, Eisenberg RJ.
(1997).
Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry.
Journal of Virology
71: 6083-93
.
|
|
|
|
|
Zarkadis IK, Omigbodun A, Forson A, Ziolkiewicz P, Kinoshita T, Lambris JD, Coutifaris C.
(1997).
Differentiation-dependent changes in human trophoblast expression of decay-accelerating factor are modulated by 3',5' cyclic adenosine monophosphate..
Journal of the Society for Gynecologic Investigation
4: 47-53
.
|
|
|
|
|
Friedman HM, Wang L, Fishman NO, Lambris JD, Eisenberg RJ, Cohen GH, Lubinski J.
(1996).
Immune evasion properties of herpes simplex virus type 1 glycoprotein gC.
Journal of Virology
70: 4253-60
.
|
|
|
|
|
Kozlowski LM, Soulika AM, Silverman GJ, Lambris JD, Levinson AI.
(1996).
Complement activation by a B cell superantigen.
Journal of Immunology
157: 1200-6
.
|
|
|
|
|
Lambris JD, Lao Z, Oglesby TJ, Atkinson JP, Hack CE, Becherer JD.
(1996).
Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component.
Journal of Immunology
156: 4821-32
.
|
|
|
|
|
Moore DJ, Lambris JD.
(1996).
Mass spectrometric analysis of the activation products of the thrid component of complement.
Techniques in Protein Chemistry VII Academic Press
7:81-91
.
|
|
|
|
Rux AH, Moore WT, Lambris JD, Abrams WR, Peng C, Friedman HM, Cohen GH, Eisenberg RJ.
(1996).
Disulfide bond structure determination and biochemical analysis of glycoprotein C from herpes simplex virus.
Journal of Virology
70: 5455-65
.
|
|
|
|
|
Sahu A, Kay BK, Lambris JD.
(1996).
Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.
Journal of Immunology
157: 884-91
.
|
|
|
|
|
Stavridi ES, O'Malley K, Lukacs CM, Moore WT, Lambris JD, Christianson DW, Rubin H, Cooperman BS.
(1996).
Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis..
Biochemistry
35: 10608-15
.
|
|
|
|
|
Sunyer JO, Zarkadis IK, Sahu A, Lambris JD.
(1996).
Multiple forms of complement C3 in trout that differ in binding to complement activators.
Proceedings of the National Academy of Sciences of the United States of America
93: 8546-51
.
|
|
|
|
|
Kozlowski LM, Lambris JD, Levinson AI.
(1995).
Effect of a putative B cell superantigen on complement.
Annals of the New York Academy of Sciences
764: 356-8
.
|
|
|
|
|
Lambris JD, Pappas J, Mavroidis M, Wang Y, Manzone H, Schwager J, Du Pasquier L, Silibovsky R, Swager J [corrected to Schwager J.
(1995).
The third component of Xenopus complement: cDNA cloning, structural and functional analysis, and evidence for an alternate C3 transcript..
European Journal of Immunology
25: 572-8
.
|
|
|
|
|
Mavroidis M, Sunyer JO, Lambris JD.
(1995).
Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family..
Journal of Immunology
154: 2164-74
.
|
|
|
|
|
Hasty LA, Brockman WW, Lambris JD, Lyttle CR.
(1994).
Hormonal regulation of complement factor B in human endometrium..
American Journal of Reproductive Immunology
30: 63-7
.
|
|
|
|
|
Hasty LA, Lambris JD, Lessey BA, Pruksananonda K, Lyttle CR.
(1994).
Hormonal regulation of complement components and receptors throughout the menstrual cycle..
American Journal of Obstetrics and Gynecology
170: 168-75
.
|
|
|
|
|
Hedrick JA, Lao Z, Lipps SG, Wang Y, Todd SC, Lambris JD, Tsoukas CD.
(1994).
Characterization of a 70-kDa, EBV gp350/220-binding protein on HSB-2 T cells..
Journal of Immunology
153: 4418-26
.
|
|
|
|
|
Hung SL, Peng C, Kostavasili I, Friedman HM, Lambris JD, Eisenberg RJ, Cohen GH.
(1994).
The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway..
Virology
203: 299-312
.
|
|
|
|
|
Lambris JD, Lao Z, Pang J, Alsenz J.
(1994).
Third component of trout complement. cDNA cloning and conservation of functional sites..
Journal of Immunology
151: 6123-34
.
|
|
|
|
|
Lambris JD, Mavroidis M, Pappas J, Lao Z, Wang Y.
(1994).
Phylogeny of the third complement component, C3, and conservation of C3-ligand interactions..
Annals of the New York Academy of Sciences
712: 354-7
.
|
|
|
|
|
Lao Z, Wang Y, Mavroidis M, Kostavasili I, Lambris JD.
(1994).
Overexpression, purification, and characterization of third component of complement..
Journal of Immunological Methods
176: 127-39
.
|
|
|
|
|
Smith CI, Baskin B, Humire-Greiff P, Zhou JN, Olsson PG, Maniar HS, Kjellén P, Lambris JD, Christensson B, Hammarström L.
(1994).
Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells..
Journal of Immunology
152: 557-65
.
|
|
|
|
|
Sinha SK, Todd SC, Hedrick JA, Speiser CL, Lambris JD, Tsoukas CD.
(1993).
Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript..
Journal of Immunology
150: 5311-20
.
|
|
|
|
|
Alsenz J, Avila D, Huemer HP, Esparza I, Becherer JD, Kinoshita T, Wang Y, Oppermann S, Lambris JD.
(1992).
Phylogeny of the third component of complement, C3: analysis of the conservation of human CR1, CR2, H, and B binding sites, concanavalin A binding sites, and thiolester bond in the C3 from different species..
Developmental and Comparative Immunology
16: 63-76
.
|
|
|
|
|
Becherer JD, Alsenz J, Esparza I, Hack CE, Lambris JD.
(1992).
Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B..
Biochemistry
31: 1787-94
.
|
|
|
|
|
Hedrick JA, Watry D, Speiser C, O'Donnell P, Lambris JD, Tsoukas CD.
(1992).
Interaction between Epstein-Barr virus and a T cell line (HSB-2) via a receptor phenotypically distinct from complement receptor type 2..
European Journal of Immunology
22: 1123-31
.
|
|
|
|
|
Kaufman J, Andersen R, Avila D, Engberg J, Lambris J, Salomonsen J, Welinder K, Skjødt K.
(1992).
Different features of the MHC class I heterodimer have evolved at different rates. Chicken B-F and beta 2-microglobulin sequences reveal invariant surface residues..
Journal of Immunology
148: 1532-46
.
|
|
|
|
|
Nilsson,B., Grossberger,D., Ekdahl,K.N., Riegert,P., Becherer,D.J., Nilsson,U.R. and Lambris,J.D.
(1992).
Conformational Differences Between Surface-Bound and Fluid-Phase Complement-Component-C3 Fragments - Epitope Mapping by Cdna Expression.
Biochemical Journal
282:715-721.
|
|
|
|
Esparza,I., Becherer,J.D., Alsenz,J., Delahera,A., Lao,Z., Tsoukas,C.D. and Lambris,J.D.
(1991).
Evidence for Multiple Sites of Interaction in C3 for Complement Receptor Type-2 (C3D/Ebv Receptor, Cd21).
European Journal of Immunology
21 (11):2829-2838.
|
|
|
|
Moller,L.B., Kaufman,J., Verland,S., Salomonsen,J., Avila,D., Lambris,J.D. and Skjodt,K.
(1991).
Variations in the Cytoplasmic Region Account for the Heterogeneity of the Chicken Mhc Class-I (B-F) Molecules.
Immunogenetics
34 (2):110-120.
|
|
|
|
Watry,D., Hedrick,J.A., Siervo,S., Rhodes,G., Lamberti,J.J., Lambris,J.D. and Tsoukas,C.D.
(1991).
Infection of Human Thymocytes by Epstein-Barr-Virus.
Journal of Experimental Medicine
173 (4):971-980.
|
|
|
|
Avila,D. and Lambris,J.D.
(1990).
Isolation and Characterization of the 3Rd Complement Component of Axolotl (Ambystoma-Mexicanum).
Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology
95 (4):839-845.
|
|
|
|
Nilsson,B., Ekdahl,K.N., Avila,D., Nilsson,U.R. and Lambris,J.D.
(1990).
Neoantigens in Complement Component-C3 As Detected by Monoclonal-Antibodies - Mapping of the Recognized Epitopes by Synthetic Peptides.
Biochemical Journal
268 (1):55-61.
|
|
|
|
Tsokos,G.C., Lambris,J.D., Finkelman,F.D., Anastassiou,E.D. and June,C.H.
(1990).
Monovalent Ligands of Complement Receptor-2 Inhibit Whereas Polyvalent Ligands Enhance Anti-Ig-Induced Human-B Cell Intracytoplasmic Free Calcium-Concentration.
Journal of Immunology
144 (5):1640-1645.
|
|
|
|
Alsenz,J., Lambris,J.D., Bork,K. and Loos,M.
(1989).
Acquired C1 Inhibitor (C1-Inh) Deficiency Type-Ii - Replacement Therapy with C1-Inh and Analysis of Patients C1-Inh and Anti-C1-Inh Autoantibodies.
Journal of Clinical Investigation
83 (6):1794-1799.
|
|
|
|
Baxevanis,C.N., Reclos,G.J., Servis,C., Anastasopoulos,E., Arsenis,P., Katsiyiannis,A., Matikas,N., Lambris,J.D. and Papamichail,M.
(1989).
Peptides of Myelin Basic-Protein Stimulate Lymphocytes-T from Patients with Multiple-Sclerosis.
Journal of Neuroimmunology
22 (1):23-30.
|
|
|
|
Bogen,B. and Lambris,J.D.
(1989).
Minimum Length of An Idiotypic Peptide and A Model for Its Binding to A Major Histocompatibility Complex Class-Ii Molecule.
Embo Journal
8 (7):1947-1952.
|
|
|
|
Dihanich,M., Vantuinen,E., Lambris,J.D. and Marshallsay,B.
(1989).
Accumulation of Viruslike Particles in A Yeast Mutant Lacking A Mitochondrial Pore Protein.
Molecular and Cellular Biology
9 (3):1100-1108.
|
|
|
|
Grossberger,D., Marcuz,A., Dupasquier,L. and Lambris,J.D.
(1989).
Conservation of Structural and Functional Domains in Complement Component C-3 of Xenopus and Mammals.
Proceedings of the National Academy of Sciences of the United States of America
86 (4):1323-1327.
|
|
|
|
Huemer,H.P., Broker,M., Larcher,C., Lambris,J.D. and Dierich,M.P.
(1989).
The Central Segment of Herpes-Simplex Virus Type-1 Glycoprotein-C (Gc) Is Not Involved in C3B Binding - Demonstration by Using Monoclonal-Antibodies and Recombinant Gc Expressed in Escherichia-Coli.
Journal of General Virology
70:1571-1578.
|
|
|
|
Lassila,O., Lambris,J.D. and Gisler,R.H.
(1989).
A Role for Lys-His-Gly-Nh2 in Avian and Murine B-Cell Development.
Cellular Immunology
122 (2):319-328.
|
|
|
|
Pluschke,G., Bordmann,G., Daoudaki,M.E., Lambris,J.D., Achtman,M. and Neibert,M.
(1989).
Isolation of Rat Igm to Igg Hybridoma Isotype Switch Variants and Analysis of the Efficiency of Rat Ig in Complement Activation.
European Journal of Immunology
19 (1):131-135.
|
|
|
|
Servis,C. and Lambris,J.D.
(1989).
C-3 Synthetic Peptides Support Growth of Human Cr2-Positive Lymphoblastoid B-Cells.
Journal of Immunology
142 (7):2207-2212.
|
|
|
|
Becherer JD, Lambris JD.
(1988).
Identification of the C3b receptor-binding domain in third component of complement..
The Journal of Biological Chemistry
263: 14586-91
.
|
|
|
|
|
Becherer,J.D. and Lambris,J.D.
(1988).
Identification of the C3B Receptor-Binding Domain in 3Rd Component of Complement.
Journal of Biological Chemistry
263 (28):14586-14591.
|
|
|
|
Daoudaki,M.E., Becherer,J.D. and Lambris,J.D.
(1988).
A 34-Amino Acid Peptide of the Third Component of Complement Mediates Properdin Binding.
Journal of Immunology
140 (5):1577-1580.
|
|
|
|
Gisler,R.H., Schlienger,C., Soderberg,A., Ledermann,F. and Lambris,J.D.
(1988).
Functional Maturation of Murine-B Lymphocyte Precursors .3. Soluble Factors Involved in the Regulation of Growth and Differentiation.
Molecular Immunology
25 (11):1113-1127.
|
|
|
|
Lambris,J.D., Avila,D., Becherer,J.D. and Mullereberhard,H.J.
(1988).
A Discontinuous Factor-H Binding-Site in the 3Rd Component of Complement As Delineated by Synthetic Peptides.
Journal of Biological Chemistry
263 (24):12147-12150.
|
|
|
|
Reclos,J.G., Baxevanis,C.N., Servis,K., Arsenis,P., Katsiyiannis,A., Matikas,N., Lambris,J.D. and Papamichail,M.
(1988).
Proliferative responces of T lymphocytes from patients with Multiple Sclerosis to human myelin basic protein peptides. In Trends in European Multiple Sclerosis research.
Elsevier Science Pub
211-215.
|
|
|
|
Tsoukas,C.D. and Lambris,J.D.
(1988).
Expression of Cr2/Ebv Receptors on Human Thymocytes Detected by Monoclonal-Antibodies.
European Journal of Immunology
18 (8):1299-1302.
|
|
|
|
Frei,Y., Lambris,J.D. and Stockinger,B.
(1987).
Generation of A Monoclonal-Antibody to Mouse C5 Application in An Elisa Assay for Detection of Anti-C5 Antibodies.
Molecular and Cellular Probes
1 (2):141-149.
|
|
|
|
Hirani,S., Lambris,J.D. and Mullereberhard,H.J.
(1986).
Structural-Analysis of the Asparagine-Linked Oligosaccharides of Human-Complement Component-C3.
Biochemical Journal
233 (2):613-616.
|
|
|
|
Tsokos,G.C., Inghirami,G. and Lambris,J.D.
(1986).
Regulation of Human Cytotoxic Responses by Complement - C-3, C3B and C3D Preparations Enhance Human Allogeneic Cytotoxic Responses.
Journal of Immunopharmacology
8 (4):529-541.
|
|
|
|
Tsonis,P.A. and Lambris,J.D.
(1986).
Similarities Between A Conserved Sequence Element of Homoeo Boxes and Other Genes.
Febs Letters
194 (2):263-266.
|
|
|
|
Aguado,M.T., Lambris,J.D., Tsokos,G.C., Burger,R., Bittersuermann,D., Tamerius,J.D., Dixon,F.J. and Theofilopoulos,A.N.
(1985).
Monoclonal-Antibodies Against Complement-3 Neoantigens for Detection of Immune-Complexes and Complement Activation - Relationship Between Immune-Complex Levels, State of C-3, and Numbers of Receptors for C3B.
Journal of Clinical Investigation
76 (4):1418-1426.
|
|
|
|
Alsenz,J., Schulz,T.F., Lambris,J.D., Sim,R.B. and Dierich,M.P.
(1985).
Structural and Functional-Analysis of the Complement Component Factor-H with the Use of Different Enzymes and Monoclonal-Antibodies to Factor-H.
Biochemical Journal
232 (3):841-850.
|
|
|
|
Hirani,S., Lambris,J.D. and Mullereberhard,H.J.
(1985).
Localization of the Conglutinin Binding-Site on the 3Rd Component of Human-Complement.
Journal of Immunology
134 (2):1105-1109.
|
|
|
|
Lambris,J.D., Hirani,S., Ganu,V.S., Becherer,D. and Müller-Eberhard,H.J.
(1985).
Synthetic peptides predicted from the nucleotide sequence of complement C3 bind to C3d receptor and monoclonal antibody 130.
Advances in Gene Technology:Molecular Biology of the Immune System
2:213-214.
|
|
|
|
Pryzwansky,K.B., Lambris,J.D., Macrae,E.K. and Schwab,J.H.
(1985).
Opsonized Streptococcal Cell-Walls Cross-Link Human-Leukocytes and Erythrocytes by Complement Receptors.
Infection and Immunity
49 (3):550-556.
|
|
|
|
Schulz,T.F., Scharfenberger,H., Lambris,J.D., Rieber,P., Riethmuller,G. and Dierich,M.P.
(1985).
Antigenic Relationship Between the Alpha-Chain of C-3, A Leucocyte-Surface Antigen Involved in the Activation of Phagocytic-Cells, and A 50,000 Mw B-Cell Antigen.
Immunology
54 (4):791-800.
|
|
|
|
Tsokos,G.C., Inghirami,G., Tsoukas,C.D., Balow,J.E. and Lambris,J.D.
(1985).
Regulation of Immunoglobulin Secretion by Factor-H of Human-Complement.
Immunology
55 (3):419-426.
|
|
|
|
Alsenz,J., Lambris,J.D., Schulz,T.F. and Dierich,M.P.
(1984).
Localization of the Complement-Component-C3B-Binding Site and the Cofactor Activity for Factor-I in the 38Kda Tryptic Fragment of Factor-H.
Biochemical Journal
224 (2):389-398.
|
|
|
|
Lambris,J.D. and Mullereberhard,H.J. (.
(1984).
Isolation and Characterization of A 33,000-Dalton Fragment of Complement Factor-B with Catalytic and C3B Binding-Activity.
Journal of, Biological Chemistry
259 (20):2685-2690.
|
|
|
|
Lambris,J.D., Alsenz,J., Schulz,T.F. and Dierich,M.P.
(1984).
Mapping of the Properdin-Binding Site in the 3Rd Component of Complement.
Biochemical Journal
217 (1):323-326.
|
|
|
|
Schulz,T.F., Scheiner,O., Alsenz,J., Lambris,J.D. and Dierich,M.P.
(1984).
Use of Monoclonal-Antibodies Against Factor-H to Investigate the Role of A Membrane-Associated Protein Antigenically Related to H in C3B-Receptor Function.
Journal of Immunology
132 (1):392-398.
|
|
|
|
Tsoukas,C.D., Lambris,J., Lotz,M., Valentine,M.A., Vaughan,J.H. and Carson,D.A.
(1984).
Lymphocyte Mitogenesis Induced by Monoclonal-Antibodies to the T3-Complex - Differential Modulation by Human-Igg.
Cellular Immunology
89 (1):66-74.
|
|
|
|
Huttfletcher,L.M., Fowler,E., Lambris,J.D., Feighny,R.J., Simmons,J.G. and Ross,G.D.
(1983).
Studies of the Epstein-Barr Virus Receptor Found on Raji Cells .2. A Comparison of Lymphocyte Binding-Sites for Epstein-Barr Virus and C3D.
Journal of Immunology
130 (3):1309-1312.
|
|
|
|
Lambris,J.D., Scheiner,O., Schulz,T.F., Alsenz,J. and Dierich,M.P.
(1983).
Coupling of C3B to Erythrocytes by Disulfide Bond Formation - Preparation of Ec3B for Hemolytic and Complement Receptor Assays.
Journal of Immunological Methods
65 (3):277-283.
|
|
|
|
Pryzwansky,K.B., Macrae,E.K. and Lambris,J.D.
(1983).
Capping of Complement Receptors on Human-Neutrophils Induced by Group-A Streptococcal Cell-Walls.
Journal of Immunology
130 (4):1674-1677.
|
|
|
|
Ross,G.D., Newman,S.L., Lambris,J.D., Deverypocius,J.E., Cain,J.A. and Lachmann,P.J.
(1983).
Generation of 3 Different Fragments of Bound C-3 with Purified Factor-I Or Serum .2. Location of Binding-Sites in the C-3 Fragments for Factor-B and Factor-H Complement Receptors, and Bovine Conglutinin.
Journal of Experimental Medicine
158 (2):334-352.
|
|
|
|
Scheiner,O., Schulz,T.F., Schmid,H.U., Lambris,J.D., Alsenz,J. and Dierich,M.P.
(1983).
Importance of Factor-H and Factor-I for the Adherence of C3B-Coated Erythrocytes to Cells.
Immunobiology
165 (2):211-224.
|
|
|
|
Lambris,J., Papamichail,M., Ioannidis,C. and Dimitracopoulos,G.
(1982).
Activation of the Alternative Pathway of Human-Complement by the Extracellular Slime Glycolipoprotein of Pseudomonas-Aeruginosa.
Journal of Infectious Diseases
145 (1):78-82.
|
|
|
|
Lambris,J.D. and Ross,G.D.
(1982).
Assay of Membrane Complement Receptors (Cr-1 and Cr-2) with C3B-Coated and C3D-Coated Fluorescent Microspheres.
Journal of Immunology
128 (1):186-189.
|
|
|
|
Lambris,J.D. and Ross,G.D.
(1982).
Characterization of the Lymphocyte Membrane-Receptor for Factor-H (Beta-1H-Globulin) with An Antibody to Anti-Factor-H Idiotype.
Journal of Experimental Medicine
155 (5):1400-1411.
|
|
|
|
Lambris,J.D., Allen,J.B. and Schwab,J.H.
(1982).
Invivo Changes in Complement Induced with Peptidoglycan-Polysaccharide Polymers from Streptococcal Cell-Walls.
Infection and Immunity
35 (1):377-380.
|
|
|
|
Ross,G.D. and Lambris,J.D.
(1982).
Identification of A C3Bi-Specific Membrane Complement Receptor That Is Expressed on Lymphocytes, Monocytes, Neutrophils, and Erythrocytes.
Journal of Experimental Medicine
155 (1):96-110.
|
|
|
|
Ross,G.D., Lambris,J.D., Cain,J.A. and Newman,S.L.
(1982).
Generation of 3 Different Fragments of Bound-C3 with Purified Factor-I Or Serum .1. Requirements for Factor-H Vs Cr-1 Cofactor Activity.
Journal of Immunology
129 (5):2051-2060.
|
|
|
|
Tsiganos,C.P., Stamatiadou,M., Lambris,J.D. and Papamichail,M.
(1982).
Detection of cartilage proteoglycan-related antigens on the surface of 3T3 cells.
Progress in Clinical & Biological Research
102 pt A:447-454.
|
|
|
|
Dobson,N.J., Lambris,J.D. and Ross,G.D.
(1981).
Characteristics of Isolated Erythrocyte Complement Receptor Type One (Cr-1, C4B-C3B Receptor) and Cr1-Specific Antibodies.
Journal of Immunology
126 (2):693-698.
|
|
|
|
Lambris,J. and Papamichail,M.
(1980).
A Method for Analyzing Lymphocyte Surface-Antigens.
Journal of Immunological Methods
34 (4):287-293.
|
|
|
|
Lambris,J., Papavassiliou,J. and Dimitracopoulos,G.
(1980).
Protein-Component of Pseudomonas-Aeruginosa Slime Glycolipoprotein in Relation to Laboratory-Induced Resistance to Gentamicin.
Canadian Journal of Microbiology
26 (7):852-853.
|
|
|
|
Lambris,J.D., Dobson,N.J. and Ross,G.D.
(1980).
Release of Endogenous C3B Inactivator from Lymphocytes in Response to Triggering Membrane-Receptors for Beta-1H Globulin.
Journal of Experimental Medicine
152 (6):1625-1644.
|
|
|
|
Lambris,J., Papamichail,M. and Fessas,P.
(1979).
Fluorescent Labeling of Proteins of Lymphocyte Plasma-Membranes.
Journal of Immunological Methods
27 (1):55-59.
|
|
|
