John D. Lambris, Ph.D.
Dr. Ralph and Sallie Weaver Professor of Research Medicine
University of Pennsylvania School of Medicine
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Biography

John D. Lambris received his Ph.D. in Biochemistry in 1979. He is the Dr. Ralph and Sallie Weaver Professor of Research Medicine in the Department of Pathology & Laboratory Medicine at the University of Pennsylvania, Philadelphia, PA. Using complement as a model system, Dr. Lambris applies ideas and methods embodied in engineering, computer science, physics, chemistry, biomedicine, and other fields to study the structure and functions of the complement system. Read more

Research Focus

Our current research efforts focus on the structural-functional aspects of protein-protein interactions and the rational design of small-size complement inhibitors. We also study the viral molecular mimicry and immune evasion strategies, as well as the evolution of complement biology. In addition, we study the involvement of various complement components with developmental pathways and the role of complement in tissue regeneration, early hematopoietic development and cancer. Read more

Inventions

Dr. Lambris is the inventor of patents and/or patent applications that describe the use of complement inhibitors for therapeutic purposes; the founder of Amyndas Pharmaceuticals, which is developing complement inhibitors (including next-generation compstatin analogues such as AMY‑101 and AMY‑106) for clinical applications, and the inventor of the compstatin technology licensed to Apellis Pharmaceuticals (4(1MeW)7W (also known as POT‑4 and APL‑1) and pegylated derivatives such asAPL-2/pegcetacoplan. Read more

Social Links

Address

Department of Pathology & Laboratory Medicine
401 Stellar-Chance labs
422 Curie Boulevard
Philadelphia, PA 19104-6100

Contact Information

Tel: (215)-746-5765 (Office)
Tel: (215)-746-5762 (Lab Administrator)
Fax: (215)-573-8738
Email: lambris@upenn.edu

Publication Metrics

(Google Scholar)
Citations > 64,526
h-index > 133
i10-index > 482

One that desires to excel should endeavor in those things that are in themselves most excellent.

Epictetus

It is possible to provide security against other ills, but as far as death is concerned, we men all live in a city without walls.

Epicurus

Work above all brings light into our lives.

Pindar

There is no human activity without obstacles.

Simonides

No good comes of idleness.

Sophocles

The one exclusive sign of thorough knowledge is the power of teaching.

Aristotle

Glory is not won through easy struggles.

Sophocles

Whenever the art of medicine is loved, there is also a love of humanity.

Hippocrates

The art of living well and the art of dying well are one.

Epicurus

Nature is used to hiding herself.

Heraclitus

One hand washes the other.

Epicharmus

Nothing is more important than hard work.

Antiphanes

The mind is not a vessel to be filled but a fire to be kindled.

Plutarch

Nothing can be attained without effort.

Musonius

Good things are accomplished through learning and hard work.

Democritus

Not to unlearn what you have learned is the most necessary kind of learning.

Antisthenes

To make no mistakes is not in the power of man; but from their errors and mistakes the wise and good learn wisdom for the future.

Plutarch

If someone is not taught then he can conquer neither art nor wisdom.

Democritus

The good should be measured by quality not quantity.

Aesop

Effort is said to be the father of fame.

Euripides

All things can be achieved through industry and effort.

Menander

No progress is made without exertion.

Sophocles

It is necessary to strive.

Euripides

A good decision is based on knowledge and not on numbers.

Plato

A ship is safer with three anchors than one.

Euripides

The race will not wait for the tardy athlete.

Fragments of the tragic poets

Work is not shameful; it is shameful not to work.

Hesiod

Even the wisest of wise men makes mistakes.

Aeschylus

There are two sides to every question.

Protagoras

Much learning does not teach understanding.

Heraclitus

Nothing great can be achieved without great risk.

Herodotus

Skillful pilots gain their reputation from storms and tempest.

Epicurus

The beginning is more than half of the whole, and when one has begun many of the things one seeks have already become known.

Aristotle

Don’t render judgment before you hear both sides.

Hesiod

Happiness resides not in posessions and not in gold; the feeling of happiness dwells in the soul.

Democritus

Neither skill nor wisdom can be achieved without knowledge.

Democritus