Articles
| Gerogianni A, Bal M, Mohlin C, Woodruff TM, Lambris JD, Mollnes TE, Sjöström DJ, Nilsson PH. (2023). In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model. Front Immunol. 14: 1101387. |  |  |
| Kuhn A, Riegger J, Teixeira GQ, Huber-Lang M, Lambris JD, Neidlinger-Wilke C, Brenner RE. (2023). Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells. Cells 12: 887. | | |
| Bechtler C, Koutsogiannaki S, Umnyakova E, Hamid A, Gautam A, Sarigiannis Y, Pouw RB, Lamers C, Rabbani S, Schmidt CQ, Lambris JD, Ricklin D. (2022). Complement-regulatory biomaterial coatings: activity and selectivity profile of the factor H-binding peptide 5C6. Acta Biomater.1742-7061(22)00712-7. | | |
| Lamers C, Xue X, Smieško M, van Son H, Wagner B, Berger N, Sfyroera G, Gros P, Lambris JD, Ricklin D. (2022). Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors. Nat Commun 13: 5519. Links: Supplemental Data. | | |
| Wang H, Ideguchi H, Kajikawa K, Mastellos DC, Lambris JD, Hajishengallis G. (2022). Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis. J Immunol. 209: 1370-1378. | | |
| Skendros P, Germanidis G, Mastellos DC, Antoniadou C, Gavriilidis E, Kalopitas G, Samakidou A, Liontos A, Chrysanthopoulou A, Ntinopoulou M, Kogias D, Karanika I, Smyrlis A, Cepaityte D, Fotiadou I, Zioga N, Mitroulis I, Gatselis NK, Papagoras C, Metallidis S, Milionis H, Dalekos GN, Willems L, Persson B, Manivel VA, Nilsson B, Connolly ES, Iacobelli S, Papadopoulos V, Calado RT, Huber-Lang M, Risitano AM, Yancopoulou D, Ritis K, Lambris JD. (2022). Complement C3 inhibition in severe COVID-19 using compstatin AMY-101. Sci Adv. 8: eabo2341. | | |
| Leonel TB, Gabrili JJM, Squaiella-Baptistão CC, Woodruff TM, Lambris JD, Tambourgi DV. (2022). Bothrops jararaca Snake Venom Inflammation Induced in Human Whole Blood: Role of the Complement System. Front Immunol. 13: 885223. | | |
| Gonçales R, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Moura CM, Delgado L, Morais A, Torrado E, L van de Veerdonk F, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A. (2022). PTX3 Inhibits Complement-Driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis. Am J Respir Crit Care Med 206: 1140-1152. | | |
| Ortiz-Espinosa S, Morales X, Senent Y, Alignani D, Tavira B, Macaya I, Ruiz B, Moreno H, Remírez A, Sainz C, Rodriguez-Pena A, Oyarbide A, Ariz M, Andueza MP, Valencia K, Teijeira A, Hoehlig K, Vater A, Rolfe B, Woodruff TM, Lopez-Picazo JM, Vicent S, Kochan G, Escors D, Gil-Bazo I, Perez-Gracia JL, Montuenga LM, Lambris JD, de Solorzano CO, Lecanda F, Ajona D, Pio R. (2021). Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. Cancer Lett. 529: 70-84. | | |
| Storm BS, Christiansen D, Fure H, Ludviksen JK, Lau C, Lambris JD, Woodruff TM, Brekke OL, Braaten T, Nielsen EW, Mollnes TE. (2021). Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood. J Immunol. 207: 2828-2840. | | |
| Hasturk H, Hajishengallis G, Lambris JD, Mastellos DC, Yancopoulou D. (2021). Phase 2a clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation. J Clin Invest. 131: e152973 Additional Links: Supplemental Data. Video. | | |
| Doni A, Parente R, Laface I, Magrini E, Cunha C, Colombo FS, Lacerda JF, Campos Jr. A, Mapelli SN, Petroni F, Porte R, Schorn T, Inforzato A, Mercier T, Lagrou K,Maertens J, Lambris JD, Bottazzi B, Garlanda C, Botto M, Carvalho A, Mantovani A. (2021). Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus. Nature Communications 12: 3739. | | |
| Schmitz R, Fitch ZW, Schroder PM, Choi AY, Manook M, Yoon J, Song M, Yi JS, Khandelwal S, Arepally GM, Farris AB, Reis ES, Lambris JD, Kwun J, Knechtle SJ. (2021). C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates. Nature Communications 12: 5456. Additional Links: Commentary. | | |
| Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev S, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB. (2021). Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes. Blood 138: 2106-2116. | | |
| Silva de Franca F, Villas-Boas IM, Cogliati B, Woodruff TM, da Silva Reis E, Lambris JD, Tambourgi DV. (2021). C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera. Frontiers in Immunology 12: 652242. | | |
| Magrini E, Di Marco S, Mapelli SN, Perucchini C, Pasqualini F, Donato A, de la Luz Guevara Lopez M, Carriero R, Ponzetta A, Colombo P, Cananzi F, Supino D, Reis ES, Peano C, Inforzato A, Jaillon S, Doni A, Lambris JD, Mantovani A, Garlanda C. (2021). Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression. Nature Cancer 2: 218–232. | | |
| Keshari RS, Silasi R, Popescu NI, Regmi G, Chaaban H, Lambris JD, Lupu C, Mollnes TE, Lupu F. (2020). CD14 inhibition improves survival and attenuates thrombo‐inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis. Journal of Thrombosis and Haemostasis 19: 429-443. | | |
| Zhang J, Song L, Pedersen DV, Li A, Lambris JD, Andersen GR, Mollnes TE, Ma YG, Garred P. (2020). Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement. eLife 9: e60908. | | |
| Halbgebauer R, Karasu E, Braun CK, Palmer A, Braumüller S, Schultze A, Schäfer F, Bückle S, Eigner A, Wachter U, Radermacher P, Resuello RGR, Tuplano JV, Nilsson Ekdahl K, Nilsson B, Armacki M, Kleger A, Seufferlein T, Kalbitz M, Gebhard F, Lambris JD, van Griensven M, Huber-Lang M. (2020). Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock. Front. Immunol. 11: 2081. | | |
| Mastellos DC, Pires da Silva BGP, Fonseca BAL, Fonseca NP, Martins MA, Mastaglio S, Ruggeri A, Sironi M, Radermacher P, Chrysanthopoulou A, Skendros P, Ritis K, Manfra I, Iacobelli S, Huber-Lang M, Nilsson B, Yancopoulou D, Connolly S, Garlanda C, Ciceri F, Risitano A, Calado RT, Lambris JD. (2020). Complement C3 vs C5 inhibition in severe COVID-19: early clinical findings reveal differential biological efficacy. Clinical Immunology 220: 108598. Additional Links: Supplement. Commentary. Letter to the Editor. | | |
| Cerniauskas E, Kurzawa‐Akanbi M, Xie L, Hallam D, Moya‐Molina M, White K, Steel D, Doherty M, Whitfield P, Al‐Aama J, Armstrong L, Kavanagh D, Lambris JD, Korolchuk VI, Harris C, Lako M. (2020). Complement modulation reverses pathology in Y402H‐retinal pigment epithelium cell model of age‐related macular degeneration by restoring lysosomal function. Stem Cells Translational Medicine 9: 1585-1603. | | |
| Skendros P, Mitsios A, Chrysanthopoulou A, Mastellos DC, Metallidis S, Rafailidis P, Ntinopoulou M, Eleni Sertaridou E, Tsironidou V, Tsigalou C, Tektonidou M, Konstantinidis T, Papagoras C, Mitroulis I, Germanidis G, Lambris JD*, Ritis K*. (2020). Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis. The Journal of Clinical Investigation. *Shared supervision. Additional Links: Commentary. E-letter. | | |
| Colineau L, Laabei M, Liu G, Ermert D, Lambris JD, Riesbeckd K, Blom AM. (2020). Interaction of Streptococcus pyogenes with extracellular matrix components resulting in immunomodulation and bacterial eradication. Matrix Biology Plus 6–7: 100020. | | |
| Lam LKM, Reilly JP, Rux AH, Murphy SJ, Kuri-Cervantes L, Weisman AR, Ittner CAG, Reilly JP, Pampena MB, Betts MR, Wherry EJ, Song WC, Lambris JD, Meyer NJ, Cines DB, Mangalmurti NS. (2020). Erythrocytes Reveal Complement Activation in Patients with COVID-19. medRxiv. | | |
| Mastaglio S, Ruggeri A, Risitano AM, Angelillo P, Yancopoulou D, Mastellos DC, Huber-Lange M, Piemontese S, Assanelli A, Garlanda C, Lambris JD, Ciceri F. (2020). The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clinical Immunology 215: 108450. | | |
| Hughes S, Gumas J, Lee R, Romano M, Berger N, Gautam AK, Sfyroera G, Chan AL, Gnanaguru G, Connor KM, Kim BJ, Dunaief JL, Ricklin D, Hajishengallis G, Yancopoulou D, Reis ES, Mastellos DC, Lambris JD. (2020). Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates. Clinical Immunology 214: 108391. Presented at the Retina Society 2020. | | |
| Baas I, Delvasto-Nuñez L, Ligthart P, Brouwer C, Folman C, Reis ES, Ricklin D, Lambris JD, Wouters D, de Haas M, Jongerius I, Zeerleder SS. (2020). Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells. Haematologica 105: e57-e60. | | |
| Akk A, Springer LE, Yang L, Hamilton-Burdess S, Lambris JD, Yan H, Hu Y, Wu X, Hourcade DE, Miller MJ, Pham CT. (2019). Complement activation on neutrophils initiates endothelial adhesion and extravasation. Molecular immunology 114: 629-642. | | |
| Devaurs D, Papanastasiou M, Antunes DA, Abella JR, Moll M, Ricklin D, Lambris JD, Kavraki LE. (2019). Native State of Complement Protein C3d Analysed via Hydrogen Exchange and Conformational Sampling. Int J Comput Biol Drug Des 11: 90-113. | | |
| Gravastrand CS, Steinkjer B, Halvorsen B, Landsem A, Skjelland M, Jacobsen EA, Woodruff TM, Lambris JD, Mollnes TE, Brekke OL, Espevik T, Rokstad AM. (2019). Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor. Journal of Immunology (Baltimore, Md.: 1950) 203: 853-863. | | |
| Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable J, Steckler C, Park I, Brock A, Lu X, Pandey R, Chandramohan A, Anand GS, Nirudodhi SN, Sperry JB, Rouse JC, Carroll JA, Rand KD, Leurs U, Weis DD, Al-Naqshabandi MA, Hageman TS, Deredge D, Wintrode PL, Papanastasiou M, Lambris JD, Li S, Urata S. (2019). Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Centroid Data Measured between 3.6 oC and 25.4 oC for the Fab Fragment of NISTmAb. J Res Natl Inst Stan 124: 124009. | | |
| Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable J, Steckler C, Park I, Brock A, Lu X, Pandey R, Chandramohan A, Anand GS, Nirudodhi SN, Sperry JB, Rouse JC, Carroll JA, Rand KD, Leurs U, Weis DD, Al-Naqshabandi MA, Hageman TS, Deredge D, Wintrode PL, Papanastasiou M, Lambris JD, Li S, Urata S. (2019). Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb. Analytical chemistry 91: 7336-7345. | | |
| Lombardi E, Matte A, Risitano AM, Ricklin D, Lambris JD, De Zanet D, Jokiranta ST, Martinelli N, Scambi C, Salvagno G, Bisoffi Z, Colato C, Siciliano A, Bortolami O, Mazzuccato M, Zorzi F, De Marco L, De Franceschi L. (2019). Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease modulating molecule. Haematologica 104: 919-928. Additional Links: Commentary. | | |
| Berger N, Alayi TD, Resuello RR, Tuplano JV, Reis ES, Lambris JD. (2018). New Analogs of the Complement C3 Inhibitor Compstatin with Increased Solubility and Improved Pharmacokinetic Profile. Journal of Medicinal Chemistry 61: 6153-6162. Additional Links: Supplement. | | |
| Bostanci N, Bao K, Li X, Maekawa T, Grossmann J, Panse C, Briones RA, Resuello RR, Tuplano JV, Garcia CA, Reis ES, Lambris JD, Hajishengallis G. (2018). Gingival Exudatome Dynamics Implicate Inhibition of the Alternative Complement Pathway in the Protective Action of the C3 Inhibitor Cp40 in Nonhuman Primate Periodontitis. Journal of Proteome Research 7: 3154-3175. | | |
| Khandelwal S, Johnson AM, Liu J, Keire D, Sommers C, Ravi J, Lee GM, Lambris JD, Reis ES, Arepally GM. (2018). Novel Immunoassay for Complement Activation by PF4/Heparin Complexes.Thrombosis and Haemostasis 118: 1484-1487. | | |
| Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. (2018). Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Research 78: 143-156. | | |
| Laabei M, Liu G, Ermert D, Lambris JD, Riesbeck K, Blom AM. (2018). Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen Moraxella catarrhalis. Journal of Immunology 201: 2721-2730. | | |
| Mukai R, Okunuki Y, Husain D, Kim CB, Lambris JD, Connor KM. (2018). The Complement System Is Critical in Maintaining Retinal Integrity during Aging. Frontiers in Aging Neuroscience 10: 15. | | |
| Mödinger Y, Rapp AE, Vikman A, Ren Z, Fischer V, Bergdolt S, Haffner-Luntzer M, Song WC, Lambris JD, Huber-Lang M, Neidlinger-Wilke C, Brenner RE, Ignatius A. (2018). Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing. Am. J Pathol. 189: 147-161. | | |
| Reis ES, Berger N, Wang X, Koutsogiannaki S, Doot RK, Gumas JT, Foukas PG, Resuello RR, Tuplano JV, Kukis D, Tarantal AF, Young AJ, Kajikawa T, Soulika AM, Mastellos DC, Yancopoulou D, Biglarnia AR, Huber-Lang M, Hajishengallis G, Nilsson B, Lambris JD. (2018). Safety profile after prolonged C3 inhibition. Clinical Immunology 197: 96-106. | | |
| Sauter RJ, Sauter M, Reis ES, Emschermann FN, Nording H, Ebenhöch S, Kraft P, Münzer P, Mauler M, Rheinlaender J, Madlung J, Edlich F, Schäffer TE, Meuth SG, Dürschmied D, Geisler T, Borst O, Gawaz M, Kleinschnitz C, Lambris JD, Langer HF. (2018). Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis. Circulation 138: 1720-1735. | | |
| van Griensven M, Ricklin D, Denk S, Halbgebauer R, Braun CK, Schultze A, Hönes F, Koutsogiannaki S, Primikyri A, Reis E, Messerer D, Hafner S, Radermacher P, Biglarnia AR, Resuello RR, Tuplano JV, Mayer B, Nilsson K, Nilsson B, Lambris JD, Huber-Lang M. (2018). Protective Effects of the Complement Inhibitor Compstatin CP40 in Hemorrhagic Shock. Shock (Augusta, Ga.) 51: 78-87. | | |
| Abicht JM, Kourtzelis I, Reichart B, Koutsogiannaki S, Primikyri A, Lambris JD, Chavakis T, Holdt L, Kind A, Guethoff S, Mayr T. (2017). Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood. Xenotransplantation 24:1. | | |
| Blatt AZ, Saggu G, Cortes C, Herbert AP, Kavanagh D, Ricklin D, Lambris JD, Ferreira VP.(2017). Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation. Frontiers in immunology 8: 1586. | | |
| Blom AM, Magda M, Kohl L, Shaughnessy J, Lambris JD, Ram S, Ermert D. (2017). Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes. Journal of Immunology 199: 3828-3839. Additional Links: In this Issue. | | |
| Denk S, Neher MD, Messerer DA, Wiegner R, Nilsson B, Rittirsch D, Nilsson-Ekdahl K, Weckbach S, Ignatius A, Kalbitz M, Gebhard F, Weiss ME, Vogt J, Radermacher P, Köhl J, Lambris JD, Huber-Lang MS. (2017). Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects. Journal of Immunology 198:4846-4854. | | |
| Denk S, Taylor RP, Wiegner R, Cook EM, Lindorfer MA, Pfeiffer K, Paschke S, Eiseler T, Weiss M, Barth E, Lambris JD, Kalbitz M, Martin T, Barth H, Messerer DA, Gebhard F, Huber-Lang MS. (2017). Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation Scandinavian Journal of Immunology 86: 143-155. | | |
| Devaurs D, Antunes DA, Papanastasiou M, Moll M, Ricklin D, Lambris JD, Kavraki LE. (2017). Coarse-Grained Conformational Sampling of Protein Structure Improves the Fit to Experimental Hydrogen-Exchange Data. Frontiers in Molecular Biosciences 4: 1-14. | | |
| Facciabene A, De Sanctis F, Pierini S, Reis ES, Balint K, Facciponte J, Rueter J, Kagabu M, Magotti P, Lanitis E, DeAngelis RA, Buckanovich RJ, Song WC, Lambris JD, Coukos G. (2017). Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy. Oncoimmunology 6: e1326442. | | |
| Grajales-Esquivel E, Luz-Madrigal A, Bierly J, Haynes T, Reis ES, Han Z, Gutierrez C, McKinney Z, Tzekou A, Lambris JD, Tsonis PA, Del Rio-Tsonis K. (2017). Complement component C3aR constitutes a novel regulator for chick eye morphogenesis. Developmental Biology 428: 88-100. | | |
| Gravastrand C, Hamad S, Fure H, Steinkjer B, Ryan L, Oberholzer J, Lambris JD, Lacík I, Mollnes TE, Espevik T, Brekke OL, Rokstad AM. (2017). Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII. Acta Biomaterialia 58: 158-167. | | |
| Harder MJ, Kuhn N, Schrezenmeier H, Höchsmann B, von Zabern I, Weinstock C, Simmet T, Ricklin D, Lambris JD, Skerra A, Anliker M, Schmidt CQ. (2017). Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation. Blood 129: 970-980. | | |
| Kajikawa T, Briones RA, Resuello RR, Tuplano JV, Reis ES, Hajishengallis E, Garcia CA, Yancopoulou D, Lambris JD, Hajishengallis G. (2017). Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Molecular Therapy. Methods & Clinical Development 6: 207-215. | | |
| Kovtun A, Bergdolt S, Hägele Y, Matthes R, Lambris JD, Huber-Lang M, Ignatius A. (2017). Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair. Scientific Reports 7: 14061. | | |
| Lindorfer MA, Cook EM, Reis ES, Ricklin D, Risitano AM, Lambris JD, Taylor RP. (2017). Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia. Clinical Immunology 171: 32-35. Additional Links: Commentary. | | |
| Papanastasiou M, Koutsogiannaki S, Sarigiannis Y, Geisbrecht BV, Ricklin D, Lambris JD. (2017). Structural Implications for the Formation and Function of the Complement Effector Protein iC3b. Journal of immunology 198: 3326-3335. Additional Links: Cover JI. | | |
| Primikyri A, Papanastasiou M, Sarigiannis Y, Koutsogiannaki S, Reis ES, Tuplano JV, Resuello RR, Nilsson B, Ricklin D, Lambris JD. (2017). Method development and validation for the quantitation of the complement inhibitor Cp40 in human and cynomolgus monkey plasma by UPLC-ESI-MS. Journal of Chromatography B. Analytical Technologies in the Biomedical and Life Sciences 1041-1042: 19-26. | | |
| Wang H, Ricklin D, Lambris JD. (2017). Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. PNAS 114: 10948-10953. | | |
| Wolf-Grosse S, Rokstad AM, Ali S, Lambris JD, Mollnes TE, Nilsen AM, Stenvik J. (2017). Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model. International Journal of Nanomedicine 12: 3927-3940. | | |
| Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D. (2017). Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis. American Journal of Physiology. Renal Physiology 312: F516-F532. | | |
| Xue X, Wu J, Ricklin D, Forneris F, Di Crescenzio P, Schmidt CQ, Granneman J, Sharp TH, Lambris JD, Gros P. (2017). Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Nature Structural & Molecular Biology 24: 643-651. | | |
| Blatt AZ, Saggu G, Kulkarni KV, Cortes C, Thurman JM, Ricklin D, Lambris JD, Valenzuela JG, Ferreira VP. (2016). Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood. Journal of Immunology 196: 4671-80. | | |
| Broders-Bondon F, Paul-Gilloteaux P, Gazquez E, Heysch J, Piel M, Mayor R, Lambris JD, Dufour S. (2016). Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin. Developmental Biology 414: 85-99. | | |
| Doerner SK, Reis ES, Leung ES, Ko JS, Heaney JD, Berger NA, Lambris JD, Nadeau JH. (2016). High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity. Molecular Cancer Research 14: 953-965. | | |
| Evgin L, Ilkow CS, Bourgeois-Daigneault MC, de Souza CT, Stubbert L, Huh MS, Jennings VA, Marguerie M, Acuna SA, Keller BA, Lefebvre C, Falls T, Le Boeuf F, Auer RA, Lambris JD, McCart JA, Stojdl DF, Bell JC. (2016). Complement inhibition enables tumor delivery of LCMV glycoprotein pseudotyped viruses in the presence of antiviral antibodies. Molecular Therapy Oncolytics 3: 16027. Additional Links: Supplement. | | |
| Forneris F, Wu J, Xue X, Ricklin D, Lin Z, Sfyroera G, Tzekou A, Volokhina E, Granneman JC, Hauhart R, Bertram P, Liszewski MK, Atkinson JP, Lambris JD, Gros P. (2016). Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode. The EMBO Journal 35: 1133-49. | | |
| Gustavsen A, Nymo S, Landsem A, Christiansen D, Ryan L, Husebye H, Lau C, Pischke SE, Lambris JD, Espevik T, Mollnes TE. (2016). Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex. The Journal of Infectious Diseases 214: 140-50. | | |
| Hajishengallis G, Krauss JL, Jotwani R, Lambris JD. (2016). Differential capacity for complement receptor-mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte. Molecular Oral Microbiology 32: 154-165. | | |
| Harder MJ, Anliker M, Höchsmann B, Simmet T, Huber-Lang M, Schrezenmeier H, Ricklin D, Lambris JD, Barlow PN, Schmidt CQ. (2016). Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation. Journal of Immunology 196 866-76. | | |
| Maekawa T, Briones RA, Resuello RR, Tuplano JV, Hajishengallis E, Kajikawa T, Koutsogiannaki S, Garcia CA, Ricklin D, Lambris JD, Hajishengallis G. (2016). Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3. Journal of Clinical Periodontology 43: 238-49. | | |
| Min JS, DeAngelis RA, Reis ES, Gupta S, Maurya MR, Evans C, Das A, Burant C, Lambris JD, Subramaniam S. (2016). Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration. Journal of Immunology 197: 2500-8. | | |
| Schmidt CQ, Harder MJ, Nichols EM, Hebecker M, Anliker M, Höchsmann B, Simmet T, Csincsi Á, Uzonyi B, Pappworth IY, Ricklin D, Lambris JD, Schrezenmeier H, Józsi M, Marchbank KJ. (2016). Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients. Immunobiology 221: 503-11. | | |
| Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero MR, Nebuloni M, Roncalli M, Colombo P, Laghi L, Lambris JD, Jaillon S, Garlanda C, Mantovani A. (2015). PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer. Cell 160: 700-14. | | |
| Evgin L, Acuna SA, Tanese de Souza C, Marguerie M, Lemay CG, Ilkow CS, Findlay CS, Falls T, Parato KA, Hanwell D, Goldstein A, Lopez R, Lafrance S, Breitbach CJ, Kirn D, Atkins H, Auer RC, Thurman JM, Stahl GL, Lambris JD, Bell JC, McCart JA. (2015). Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques. Molecular Therapy 23: 1066-76. | | |
| Georgoutsou-Spyridonos M, Ricklin D, Pratsinis H, Perivolioti E, Pirmettis I, Garcia BL, Geisbrecht BV, Foukas PG, Lambris JD, Mastellos DC, Sfyroera G. (2015). Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb. Journal of Immunology 195: 3946-58. Additional Links: Top 10% of October 2015. | | |
| Hamad OA, Mitroulis I, Fromell K, Kozarcanin H, Chavakis T, Ricklin D, Lambris JD, Ekdahl KN, Nilsson B. (2015). Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18. Thrombosis and Haemostasis 114: 1207-17. | | |
| Kourtzelis I, Ferreira A, Mitroulis I, Ricklin D, Bornstein SR, Waskow C, Lambris JD, Chavakis T. (2015). Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium. Hormone and Metabolic 47: 36-42. | | |
| Lin Z, Schmidt CQ, Koutsogiannaki S, Ricci P, Risitano AM, Lambris JD, Ricklin D. (2015). Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria. Blood 126: 891-4. | | |
| Rafail S, Kourtzelis I, Foukas PG, Markiewski MM, DeAngelis RA, Guariento M, Ricklin D, Grice EA, Lambris JD. (2015). Complement deficiency promotes cutaneous wound healing in mice. Journal of Immunology 194: 1285-91. | | |
| Reis ES, DeAngelis RA, Chen H, Resuello RR, Ricklin D, Lambris JD. (2015). Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters. Immunobiology 220: 476-82. | | |
| Sfyroera G, Ricklin D, Reis ES, Chen H, Wu EL, Kaznessis YN, Ekdahl KN, Nilsson B, Lambris JD. (2015). Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity. Journal of Immunology 194: 3305-16. | | |
| Silasi-Mansat R, Zhu H, Georgescu C, Popescu N, Keshari RS, Peer G, Lupu C, Taylor FB, Pereira HA, Kinasewitz G, Lambris JD, Lupu F. (2015). Complement inhibition decreases early fibrogenic events in the lung of septic baboons. Journal of Cellular and Molecular Medicine 19: 2549-63. | | |
| Sweigard JH, Matsumoto H, Smith KE, Kim LA, Paschalis EI, Okonuki Y, Castillejos A, Kataoka K, Hasegawa E, Yanai R, Husain D, Lambris JD, Vavvas D, Miller JW, Connor KM. (2015). Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. Science Translational Medicine 7: 297ra116. | | |
| Taketani M, Donia MS, Jacobson AN, Lambris JD, Fischbach MA. (2015). A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron. mBio 6: e01339-15. | | |
| Wang J, Wang L, Xiang Y, Ricklin D, Lambris JD, Chen G. (2015). Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40. Clinical immunology 162: 37-44. | | |
| Zhang Y, Shao D, Ricklin D, Hilkin BM, Nester CM, Lambris JD, Smith RJ. (2015). Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy. Immunobiology 220: 993-8. | | |
| Clarkson BD, Ling C, Shi Y, Harris MG, Rayasam A, Sun D, Salamat MS, Kuchroo V, Lambris JD, Sandor M, Fabry Z. (2014). T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice. The Journal of Experimental Medicine 211: 595-604. | | |
| Egge KH, Thorgersen EB, Lindstad JK, Pharo A, Lambris JD, Barratt-Due A, Mollnes TE. (2014). Post-challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood. Innate Immunity 20: 68-77. | | |
| Forn-Cuní G, Reis ES, Dios S, Posada D, Lambris JD, Figueras A, Novoa B. (2014). The Evolution and Appearance of C3 Duplications in Fish Originate an Exclusive Teleost c3 Gene Form with Anti-Inflammatory Activity. PloS one 9: 9(6):e99673. | | |
| Huang Y, Reis ES, Knerr PJ, van der Donk WA, Ricklin D, Lambris JD. (2014). Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin. ChemMedChem 9: 2223-6. | | |
| Keshari RS, Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Chaaban H, Lambris JD, Polf H, Lupu C, Kinasewitz G, Lupu F. (2014). Acute Lung Injury and Fibrosis in a Baboon Model of Escherichia coli Sepsis. American Journal of Respiratory Cell and Molecular Biology 50: 439-50. | | |
| Klapper Y, Hamad OA, Teramura Y, Leneweit G, Nienhaus GU, Ricklin D, Lambris JD, Ekdahl KN, Nilsson B. (2014). Mediation of a non-proteolytic activation of complement component C3 by phospholipid vesicles. Biomaterials 35: 3688-96. | | |
| Maekawa T, Abe T, Hajishengallis E, Hosur KB, DeAngelis RA, Ricklin D, Lambris JD, Hajishengallis G. (2014). Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis. Journal of Immunology 192: 6020-7. | | |
| Maekawa T, Krauss JL, Abe T, Jotwani R, Triantafilou M, Triantafilou K, Hashim A, Hoch S, Curtis MA, Nussbaum G, Lambris JD, Hajishengallis G. (2014). Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis. Cell Host & Microbe 15: 768-78. | | |
| Moll G, Alm JJ, Davies LC, von Bahr L, Heldring N, Stenbeck-Funke L, Hamad OA, Hinsch R, Ignatowicz L, Locke M, Lönnies H, Lambris JD, Teramura Y, Nilsson-Ekdahl K, Nilsson B, Le Blanc K. (2014). Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties? Stem Cells 32: 2430-42. | | |
| Risitano AM, Ricklin D, Huang Y, Reis ES, Chen H, Ricci P, Lin Z, Pascariello C, Raia M, Sica M, Del Vecchio L, Pane F, Lupu F, Notaro R, Resuello RR, Deangelis RA, Lambris JD. (2014). Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria. Blood 123: 2094-101. Additional Links: Inside Blood, Supplement. | | |
| Samstad EO, Niyonzima N, Nymo S, Aune MH, Ryan L, Bakke SS, Lappegård KT, Brekke OL, Lambris JD, Damås JK, Latz E, Mollnes TE, Espevik T. (2014). Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. Journal of Immunology 192: 2837-45. | | |
| Song D, Grieco S, Li Y, Hunter A, Chu S, Zhao L, Song Y, DeAngelis RA, Shi LY, Liu Q, Pierce EA, Nishina PM, Lambris JD, Dunaief JL. (2014). A murine RP1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration. The American Journal of Pathology 184: 2721-9. | | |
| Sweigard JH, Yanai R, Gaissert P, Saint-Geniez M, Kataoka K, Thanos A, Stahl GL, Lambris JD, Connor KM. (2014). The alternative complement pathway regulates pathological angiogenesis in the retina. FASEB Journal 28 : 3171-82. | | |
| Woehl JL, Stapels DA, Garcia BL, Ramyar KX, Keightley A, Ruyken M, Syriga M, Sfyroera G, Weber AB, Zolkiewski M, Ricklin D, Lambris JD, Rooijakkers SH, Geisbrecht BV. (2014). The Extracellular Adherence Protein from Staphylococcus aureus Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase. Journal of Immunology (Baltimore, Md.: 1950) 193: 6161-71. | | |
| Chehoud C, Rafail S, Tyldsley AS, Seykora JT, Lambris JD, Grice EA. (2013). Complement modulates the cutaneous microbiome and inflammatory milieu. Proceedings of the National Academy of Sciences of the United States of America 110: 15061-6. | | |
| Garcia BL, Summers BJ, Ramyar KX, Tzekou A, Lin Z, Ricklin D, Lambris JD, Laity JH, Geisbrecht BV. (2013). A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins. The Journal of Biological Chemistry 288: 2870-81. | | |
| Garland DL, Fernandez-Godino R, Kaur I, Speicher KD, Harnly JM, Lambris JD, Speicher DW, Pierce EA. (2013). Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration. Human Molecular Genetics 23: 52-68. | | |
| Guimond DM, Cam NR, Hirve N, Duan W, Lambris JD, Croft M, Tsoukas CD. (2013). Regulation of Immune Responsiveness In Vivo by Disrupting an Early T-Cell Signaling Event Using a Cell-Permeable Peptide. PloS one 8: e63645. | | |
| Haynes T, Luz-Madrigal A, Reis ES, Echeverri Ruiz NP, Grajales-Esquivel E, Tzekou A, Tsonis PA, Lambris JD, Del Rio-Tsonis K. (2013). Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nature communications 4 : 2312. Additional Links: Supplement. | | |
| Kourtzelis I, Rafail S, DeAngelis RA, Foukas PG, Ricklin D, Lambris JD. (2013). Inhibition of biomaterial-induced complement activation attenuates the inflammatory host response to implantation. FASEB journal : Official Publication of the Federation of American Societies for Experimental Biology 27: 2768-76. | | |
| Landsem A, Nielsen EW, Fure H, Christiansen D, Ludviksen JK, Lambris JD, sterud B, Mollnes TE, Brekke OL. (2013). C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood. Clinical and Experimental Immunology 173: 217-29. | | |
| Oikonomopoulou K, DeAngelis RA, Chen H, Diamandis EP, Hollenberg MD, Ricklin D, Lambris JD. (2013). Induction of complement C3a receptor responses by kallikrein-related peptidase 14. Journal of Immunology 191: 3858-66. | | |
| Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T. (2013). The complement anaphylatoxin c5a receptor contributes to obese adipose tissue inflammation and insulin resistance. Journal of Immunology 191 : 4367-74. | | |
| Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, Deangelis RA, Resuello RR, Lupu F, Barlow PN, Lambris JD. (2013). New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology 218: 496-505. Additional Links: Supplement. | | |
| Schmidt CQ, Bai H, Lin Z, Risitano AM, Barlow PN, Ricklin D, Lambris JD. (2013). Rational engineering of a minimized immune inhibitor with unique triple-targeting properties. Journal of Immunology 190: 5712-21. | | |
| Yang K, Dinasarapu AR, Reis ES, Deangelis RA, Ricklin D, Subramaniam S, Lambris JD. (2013). CMAP: Complement Map Database. Bioinformatics 29: 1832-3. | | |
| Abe T, Hosur KB, Hajishengallis E, Reis ES, Ricklin D, Lambris JD, Hajishengallis G. (2012). Local complement-targeted intervention in periodontitis: proof-of concept using a C5a receptor (CD88) antagonist. Journal of immunology 189: 5442-8. | | |
| Corrales L, Ajona D, Rafail S, Lasarte JJ, Riezu-Boj JI, Lambris JD, Rouzaut A, Pajares MJ, Montuenga LM, Pio R. (2012). Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression. Journal of immunology 189: 4674-83. | | |
| Deangelis RA, Markiewski MM, Kourtzelis I, Rafail S, Syriga M, Sandor A, Maurya MR, Gupta S, Subramaniam S, Lambris JD. (2012). A Complement-IL-4 Regulatory Circuit Controls Liver Regeneration. Journal of immunology 188: 641-8. | | |
| Fisette A, Munkonda MN, Oikonomopoulou K, Paglialunga S, Lambris JD, Cianflone K. (2012). C5L2 receptor disruption enhances the development of diet-induced insulin resistance in mice Immunobiology 218: 127-33. | | |
| Garcia BL, Summers BJ, Lin Z, Ramyar KX, Ricklin D, Kamath DV, Fu ZQ, Lambris JD, Geisbrecht BV. (2012). Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family. The Journal of Biological Chemistry 287: 628-40. | | |
| Giacomelli S, Melillo D, Lambris JD, Pinto MR. (2012). Immune competence of the Ciona intestinalis pharynx: Complement system-mediated activity. Fish & Shellfish Immunology 33: 946-952. | | |
| Harboe M, Garred P, Lindstad JK, Pharo A, Müller F, Stahl GL, Lambris JD, Mollnes TE. (2012). The Role of Properdin in Zymosan- and Escherichia coli-Induced Complement Activation. Journal of Immunology 189: 2606–2613. | | |
| Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, Göbel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T. (2012). Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis Circulation Research 110(9): 1202-10. | | |
| Nilsson PH, Ekdahl KN, Magnusson PU, Qu H, Iwata H, Ricklin D, Hong J, Lambris JD, Nilsson B, Teramura Y. (2012). Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating. Biomaterials 34: 985-94. | | |
| Nunez-Cruz S, Gimotty PA, Guerra MW, Connolly DC, Wu YQ, DeAngelis RA, Lambris JD, Coukos G, Scholler N. (2012). Genetic and pharmacologic inhibition of complement impairs endothelial cell function and ablates ovarian cancer neovascularization. Neoplasia 14: 994-1004. Additional Links: Neoplasia cover. | | |
| Reis ES, Chen H, Sfyroera G, Monk PN, Köhl J, Ricklin D, Lambris JD. (2012). C5a receptor-dependent cell activation by physiological concentrations of desarginated c5a: Insights from a novel label-free cellular assay. Journal of Immunology 189: 4797-805. Additional Links: In this Issue. | | |
| Rokstad AM, Brekke OL, Steinkjer B, Ryan L, Kolláriková G, Strand BL, Skjåk-Bræk G, Lambris JD, Lacík I, Mollnes TE, Espevik T. (2012). The induction of cytokines by polycation containing microspheres by a complement dependent mechanism. Biomaterials 34: 621-30. | | |
| Sokolov A, Hellerud BC, Lambris JD, Johannessen EA, Mollnes TE. (2012). Activation of polymorphonuclear leukocytes by candidate biomaterials for an implantable glucose sensor. Journal of Diabetes Science and Technology 5: 1490-8. | | |
| Yang K, Deangelis RA, Reed JE, Ricklin D, Lambris JD. (2012). Complement in action: An analysis of patent trends from 1976 through 2011. Advances in Experimental Medicine and Biology 734: 301-13. | | |
| Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Lissina O, Lambris JD, Nunn MA, Mollnes TE. (2011). Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans. Journal of Immunology 187: 4913-9. | | |
| Bergseth G, Lambris JD, Mollnes TE, Lappegård KT. (2011). Artificial surface-induced inflammation relies on complement factor 5: proof from a deficient person. The Annals of Thoracic Surgery 91: 527-33. | | |
| Brekke OL, Hellerud BC, Christiansen D, Fure H, Castellheim A, Nielsen EW, Pharo A, Lindstad JK, Bergseth G, Leslie G, Lambris JD, Brandtzaeg P, Mollnes TE. (2011). Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood. Molecular Immunology 48: 2159-69. | | |
| Carmona-Fontaine C, Theveneau E, Tzekou A, Tada M, Woods M, Page KM, Parsons M, Lambris JD, Mayor R. (2011). Complement fragment C3a controls mutual cell attraction during collective cell migration. Developmental Cell 21: 1026-37. Additional Links: Supplementary information. | | |
| Engberg AE, Rosengren-Holmberg JP, Chen H, Nilsson B, Lambris JD, Nicholls IA, Ekdahl KN. (2011). Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility. Journal of biomedical materials research. Part A 97: 74-84. | | |
| Forneris F, Ricklin D, Wu J, Tzekou A, Wallace RS, Lambris JD, Gros P. (2011). Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science 330: 1816-20. Additional Links: Supplementary Information. | | |
| Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA. (2011). Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement.Cell Host & Microbe 10: 1–10. | | |
| Hallström T, Nordström T, Tan TT, Manolov T, Lambris JD, Isenman DE, Zipfel PF, Blom AM, Riesbeck K. (2011). Immune Evasion of Moraxella catarrhalis Involves Ubiquitous Surface Protein A-Dependent C3d Binding. Journal of Immunology 186: 3120-9. | | |
| Ignatius A, Ehrnthaller C, Brenner RE, Kreja L, Schoengraf P, Lisson P, Blakytny R, Recknagel S, Claes L, Gebhard F, Lambris JD, Huber-Lang M. (2011). The Anaphylatoxin Receptor C5aR Is Present During Fracture Healing in Rats and Mediates Osteoblast Migration In Vitro. The Journal of Trauma 71(4): 952-960. | | |
| Ignatius A, Schoengraf P, Kreja L, Liedert A, Recknagel S, Kandert S, Brenner RE, Schneider M, Lambris JD, Huber-Lang M. (2011). Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β. Journal of Cellular Biochemistry 112: 2594-605. | | |
| Kashem SW, Subramanian H, Collington SJ, Magotti P, Lambris JD, Ali H. (2011). G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2. European Journal of Pharmacology 668: 299-304. | | |
| Knerr PJ, Tzekou A, Ricklin D, Qu H, Chen H, van der Donk WA, Lambris JD. (2011). Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. ACS Chemical Biology 6: 753-60. | | |
| Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, Li F, Tzekou A, Lambris JD, Hajishengallis G. (2011). The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. Journal of immunology 186: 869-77. | | |
| Moll G, Jitschin R, von Bahr L, Rasmusson-Duprez I, Sundberg B, Lönnies L, Elgue G, Nilsson-Ekdahl K, Mougiakakos D, Lambris JD, Ringdén O, Le Blanc K, Nilsson B. (2011). Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses. PloS One 6: e21703. | | |
| Pavlov VI, La Bonte LR, Baldwin WM, Markiewski MM, Lambris JD, Stahl GL. (2011). Absence of mannose-binding lectin prevents hyperglycemic cardiovascular complications. The American Journal of Pathology 180: 104-12. | | |
| Qu H, Magotti P, Ricklin D, Wu EL, Kourtzelis I, Wu YQ, Kaznessis YN, Lambris JD. (2011). Novel analogues of the therapeutic complement inhibitor compstatin with significantly improved affinity and potency. Molecular Immunology 48: 481-9. | | |
| Recknagel S, Bindl R, Kurz J, Wehner T, Schoengraf P, Ehrnthaller C, Qu H, Gebhard F, Huber-Lang M, Lambris JD, Claes L, Ignatius A. (2011). C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing. Journal of Orthopaedic Research 30: 581-6. | | |
| Strey CW, Marquez-Pinilla RM, Markiewski MM, Siegmund B, Oppermann E, Lambris JD, Bechstein WO. (2011). Early post-operative measurement of cytokine plasma levels combined with pre-operative bilirubin levels identify high-risk patients after liver resection. International Journal of Molecular Medicine 27: 447-54. | | |
| Subramanian H, Kashem SW, Collington SJ, Qu H, Lambris JD, Ali H (2011). PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Molecular Pharmacology 79:: 1005-13. | | |
| Suetsugu-Maki R, Maki N, Fox TP, Nakamura K, Cowper Solari R, Tomlinson CR, Qu H, Lambris JD, Tsonis PA. (2011). A complement receptor C5a antagonist regulates epithelial to mesenchymal transition and crystallin expression after lens cataract surgery in mice. Molecular Vision 17: 949-64. | | |
| Wu YQ, Qu H, Sfyroera G, Tzekou A, Kay BK, Nilsson B, Nilsson Ekdahl K, Ricklin D*, Lambris JD*. (2011). Protection of nonself surfaces from complement attack by factor h-binding peptides: implications for therapeutic medicine. Journal of Immunology 186: 4269-77. *Shared supervision. Additional Links: Erratum. | | |
| Amara U, Flierl MA, Rittirsch D, Klos A, Chen H, Acker B, Brückner UB, Nilsson B, Gebhard F, Lambris JD, Huber-Lang M. (2010). Molecular Intercommunication between the Complement and Coagulation Systems. Journal of Immunology 185: 5628-36. | | |
| Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Brekke OL, Christiansen D, Lambris JD, Mollnes TE. (2010). Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood. Molecular immunology 47: 1774-82. | | |
| Chi ZL, Yoshida T, Lambris JD, Iwata T. (2010). Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration. Advances in Experimental Medicine and Biology 703: 127-35. | | |
| Chen H, Ricklin D, Hammel M, Garcia BL, McWhorter WJ, Sfyroera G, Wu YQ, Tzekou A, Li S, Geisbrecht BV, Woods VL, Lambris JD. (2010). Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proceedings of the National Academy of Sciences of the United States of America 107: 17621-6. Additional Links: Supplementary Information. | | |
| Danielsson A, Elgue G, Nilsson BM, Nilsson B, Lambris JD, Tötterman TH, Kochanek S, Kreppel F, Essand M. (2010). An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood. Gene Therapy 17: 752-62. | | |
| Deak E, Jayakumar A, Cho KW, Goldsmith-Pestana K, Dondji B, Lambris JD, McMahon-Pratt D. (2010). Murine visceral leishmaniasis: IgM and polyclonal B-cell activation lead to disease exacerbation. European Journal of Immunology 40: 1355-68. | | |
| Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, Lambris JD, Geisbrecht BV. (2010). Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. Journal of Molecular Biology 402: 17-29. | | |
| Grasis JA, Guimond DM, Cam NR, Herman K, Magotti P, Lambris JD, Tsoukas CD. (2010). In vivo significance of ITK-SLP-76 interaction in cytokine production. Molecular and cellular biology 30: 3596-609. | | |
| Hamad OA, Nilsson PH, Lasaosa M, Ricklin D, Lambris JD, Nilsson B, Ekdahl KN. (2010). Contribution of chondroitin sulfate A to the binding of complement proteins to activated platelets. PloS one 5: e12889. | | |
| Hamad OA, Nilsson PH, Wouters D, Lambris JD, Ekdahl KN, Nilsson B. (2010). Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1. Journal of Immunology 184: 2686-92. | | |
| Haspel N, Geisbrecht BV, Lambris JD, Kavraki L. (2010). Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex. Proteins 78: 1004-14. | | |
| Kourtzelis I, Markiewski MM, Doumas M, Rafail S, Kambas K, Mitroulis I, Panagoutsos S, Passadakis P, Vargemezis V, Magotti P, Qu H, Mollnes TE, Ritis K, Lambris JD. (2010). Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis. Blood 116: 631-9. | | |
| Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, Deangelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD*, Chavakis T*. (2010). Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood 116: 4395-403 *Shared supervision. | | |
| Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Sfyroera G, Magotti P, Ivanciu L, Lupu C, Mollnes TE, Taylor FB, Kinasewitz G, Lambris JD*, Lupu F* (2010). Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood 116: 1002-10 *Shared supervision. | | |
| Strey CW, Gestrich J, Beckhaus T, Marquez-Pinilla RM, Oppermann E, Mönch C, Lambris JD, Karas M, Bechstein WO. (2010). Hypoxia and reoxygenation of primary human hepatocytes induce proteome changes of glucose metabolism oxidative protection and peroxisomal function. International Journal of Molecular Medicine 26: 577-84. | | |
| Strey CW, Siegmund B, Rosenblum S, Marquez-Pinilla RM, Oppermann E, Huber-Lang M, Lambris JD, Bechstein WO. (2010). Complement and neutrophil function changes after liver resection in humans. World Journal of Surgery 33: 2635-43. | | |
| Wang M, Krauss JL, Domon H, Hosur KB, Liang S, Magotti P, Triantafilou M, Triantafilou K, Lambris JD, Hajishengallis G. (2010). Microbial hijacking of complement-toll-like receptor crosstalk.Science Signaling 16: 3(109): ra11. Additional Links: Podcast, Perspectives, Supplementary Information. | | |
| Garcia BL, Tzekou A, Ramyar KX, McWhorter WJ, Ricklin D, Lambris JD, Geisbrecht BV. (2009). Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN). Acta crystallographica. Section F, Structural biology and crystallization communications 65: 482-5. | | |
| Georgopoulos LJ, Elgue G, Sanchez J, Dussupt V, Magotti P, Lambris JD, Tötterman TH, Maitland NJ, Nilsson B. (2009). Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood. Molecular Immunology 46: 2911-7. | | |
| Hill-Baskin AE, Markiewski MM, Buchner DA, Shao H, DeSantis D, Hsiao G, Subramaniam S, Berger NA, Croniger C, Lambris JD, Nadeau JH. (2009). Diet-induced hepatocellular carcinoma in genetically predisposed mice. Human Molecular Genetics 18: 2975-88. | | |
| Lappegård KK, Christiansen DD, Pharo AA, Thorgersen EE, Hellerud BB, Lindstad JJ, Nielsen EE, Bergseth GG, Fadnes DD, Abrahamsen TT, Høiby EA, Schejbel LL, Garred PP, Lambris JD, Harboe MM, Mollnes TT. (2009). Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature. Proceedings of the National Academy of Sciences of the United States of America 106: 15861-6. | | |
| Magotti P, Ricklin D, Qu H, Wu YQ, Kaznessis YN, Lambris JD. (2009). Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin. Journal of Molecular Recognition 22: 495-505. | | |
| Mangsbo SM, Sanchez J, Anger K, Lambris JD, Ekdahl KN, Loskog AS, Nilsson B, Totterman TH. (2009). Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects. J Immunol 183: 6724-32. Additional Links: Supplementary Information. | | |
| Nakayama Y, Kim SI, Kim EH, Lambris JD, Sandor M, Suresh M. (2009). C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection. Journal of Immunology 183: 2921-31. | | |
| Petrou PS, Ricklin D, Zavali M, Raptis I, Kakabakos SE, Misiakos K, Lambris JD. (2009). Real-time label-free detection of complement activation products in human serum by white light reflectance spectroscopy. Biosensors & Bioelectronics 24: 3359-64. | | |
| Qu H, Magotti P, Ricklin D, Lambris JD. (2009). Development of Compstatin Derivative-Albumin Binding Peptide Chimeras for Prolonged Plasma Half-Life. Proceedings of the 21st American Peptide Symposium : 219-220. | | |
| Ricklin D, Tzekou A, Garcia BL, Hammel M, McWhorter WJ, Sfyroera G, Wu YQ, Holers VM, Herbert AP, Barlow PN, Geisbrecht BV, Lambris JD. (2009). A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. Journal of Immunology 183: 2565-74. | | |
| Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P. (2009). Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nature Immunology 10: 721-7. Additional Links: Supplementary Information. | | |
| Thorgersen EB, Ludviksen JK, Lambris JD, Sfyroera G, Nielsen EW, Mollnes TE. (2009). Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity. Innate Immunity 16: 254-64. | | |
| Wu J, Wu YQ, Ricklin D, Janssen BJ, Gros P, Lambris JD. (2009). Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nature Immunology 10: 728-33. Additional Links: Supplementary Information. | | |
| Chen H, Schuster MC, Sfyroera G, Geisbrecht BV, Lambris JD. (2008). Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry. Journal of the American Society for Mass Spectrometry 19: 55-65. | | |
| Chiu TL, Mulakala C, Lambris JD, Kaznessis YN. (2008). Development of a new pharmacophore model that discriminates active compstatin analogs. Chemical Biology & Drug Design 72: 249-56. | | |
| Fleming SD, Phillips LM, Lambris JD, Tsokos GC. (2008). Complement component C5a mediates hemorrhage-induced intestinal damage. The Journal of Surgical Research 150: 196-203. | | |
| Goto M, Tjernberg J, Dufrane D, Elgue G, Brandhorst D, Ekdahl KN, Brandhorst H, Wennberg L, Kurokawa Y, Satomi S, Lambris JD, Gianello P, Korsgren O, Nilsson B. (2008). Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation 15: 225-34. | | |
| Hadziahmetovic M, Dentchev T, Song Y, Haddad N, He XN, Hahn P, Pratico D, Wen R, Harris ZL, Lambris JD, Beard J, Dunaief JL. (2008). Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Investigative Ophthalmology & Visual Science 49: 2728-2736. | | |
| Hamad OA, Eldahi KN, Nilsson PH, Andersson J, Magotti P, Lambris JD, Nilsson B. (2008). Complement activation triggered by chondroitin sulfare released by thrombin receptoractivated platelets. Journal of Thromb Haemost 6: 1413-1421. | | |
| Haspel N, Ricklin D, Geisbrecht BV, Kavraki LE, Lambris JD. (2008). Electrostatic Contributions Drive the Interaction Between Staphylococcus aureus Protein Efb-C and its Complement Target C3d. Protein Science 17: 1894-1906. Additional Links: Supplementary Material. | | |
| Hellerud BC, Stenvik J, Espevik T, Lambris JD, Mollnes TE, Brandtzaeg P. (2008). Stages of meningococcal sepsis simulated in vitro, with emphasis on complement and Toll-like receptor activation. Infection and Immunity 76: 4183-9. | | |
| Kambas K, Markiewski MM, Pneumatikos IA, Rafail S, Theodorou V, Konstantonis D, Kourtzelis I, Doumas MN, Magotti P, DeAngelis RA, Lambris JD*, Ritis KD*. (2008). C5a and TNF-{alpha} up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome. Journal of Immunology 180: 7368-7375. *co-supervised this work. | | |
| Lappegård KT, Bergseth G, Riesenfeld J, Pharo A, Magotti P, Lambris JD, Mollnes TE. (2008). The artificial surface-induced whole blood inflammatory reaction revealed by increases in a series of chemokines and growth factors is largely complement dependent. Journal of Biomedical Materials Research. Part A 87: 129-35. | | |
| Markiewski MM, DeAngelis RA, Benencia F, Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, Coukos G, Lambris JD. (2008). Modulation of the anti-tumor immune response by complement. Nature Immunology 9(11): 1225-1235. Additional Links: Nature Biotechnology News & Views, Nature Cancer Reviews Highlight, Nature Immunology News & Views, Supplementary Information. | | |
| Ricklin D, Ricklin-Lichtsteiner SK, Markiewski MM, Geisbrecht BV, Lambris JD. (2008). Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2. Journal of Immunology 181: 7463-7. | | |
| Rynkowski MA, Kim GH, Garrett MC, Zacharia BE, Otten ML, Sosunov SA, Komotar RJ, Hassid BG, Ducruet AF, Lambris JD, Connolly ES. (2008). C3a receptor antagonist attenuates brain injury after intracerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism 29: 98-107. | | |
| Saethre M, Schneider MK, Lambris JD, Magotti P, Haraldsen G, Seebach JD, Mollnes TE. (2008). Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model. Journal of Immunology 180: 6346-53. | | |
| Schuster MC, Ricklin D, Papp K, Molnar KS, Coales SJ, Hamuro Y, Sfyroera G, Chen H, Winters MS, Lambris JD. (2008). Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry. Molecular Immunology 45: 3142-51. | | |
| Tjernberg J, Ekdahl KN, Lambris JD, Korsgren O, Nilsson B. (2008). Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation 85: 1193-9. | | |
| Zucchetti I, Marino R, Pinto MR, Lambris JD, Du Pasquier L, De Santis R. (2008). ciCD94-1, an ascidian multipurpose C-type lectin-like receptor expressed in Ciona intestinalis hemocytes and larval neural structures. Differentiation 76: 267-82. | | |
| Hammel M, Sfyroera G, Pyrpassopoulos S, Ricklin D, Ramyar KX, Pop M, Jin Z, Lambris JD, Geisbrecht BV. (2007). Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus. The Journal of Biological Chemistry 282: 30051-61. | | |
| Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV. (2007). A structural basis for complement inhibition by Staphylococcus aureus. Nature Immunology 8: 430-7. Additional Links: Science Editor's Choice. | | |
| Janssen BJ, Halff EF, Lambris JD, Gros P. (2007). Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. The Journal of Biological Chemistry 282: 29241-7. Additional Links: Supplementary Information. | | |
| Józsi M, Oppermann M, Lambris JD, Zipfel PF. (2007). The C-terminus of complement factor H is essential for host cell protection. Molecular Immunology 44: 2697-706. | | |
| Montalvo V, Campos MM, Chan CC, Wawrousek EF, Bush RA, Lambris JD, Gery I. (2007). Complement deposits on ocular tissues adjacent to sites of inflammation. Current Eye Research 32: 917-22. | | |
| Mulakala C, Lambris JD, Kaznessis Y. (2007). A simple, yet highly accurate, QSAR model captures the complement inhibitory activity of compstatin. Bioorganic & Medicinal Chemistry 15: 1638-44. | | |
| Pedersen ED, Aass HC, Rootwelt T, Fung M, Lambris JD, Mollnes TE. (2007). CD59 efficiently protects human NT2-N neurons against complement-mediated damage. Scandinavian Journal of Immunology 66: 345-51. | | |
| Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B, Sher A, Litke AM, Lambris JD, Smith SJ, John SW, Barres BA. (2007). The classical complement cascade mediates CNS synapse elimination. Cell 131: 1164-78. Additional Links: Cell Preview, Science News of The Week. | | |
| Tamamis P, Skourtis SS, Morikis D, Lambris JD, Archontis G. (2007). Conformational analysis of compstatin analogues with molecular dynamics simulations in explicit water. Journal of Molecular Graphics & Modeling 26: 571-80. | | |
| Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. (2007). C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. Journal of Immunology 178: 1819-28. | | |
| Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris JD, Wetsel RA, Miwa T, Song WC. (2007). Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110: 228-36. | | |
| Anderson AL, Sporici R, Lambris J, Larosa D, Levinson AI. (2006). Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infection and Immunity 74: 1196-203. | | |
| Drouin SM, Sinha M, Sfyroera G, Lambris JD, Wetsel RA. (2006). A protective role for the fifth complement component (c5) in allergic airway disease. American Journal of Respiratory and Critical Care Medicine 173: 852-7. | | |
| Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA. (2006). Generation of C5a in the absence of C3: a new complement activation pathway. Nature Medicine 12: 682-7. | | |
| Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P. (2006). Structure of C3b reveals conformational changes that underlie complement activity. Nature 444: 213-6. Additional Links: News & Views. | | |
| Katragadda M, Lambris JD. (2006). Expression of compstatin in Escherichia coli: incorporation of unnatural amino acids enhances its activity. Protein Expression and Purification 47: 289-95. | | |
| Katragadda M, Magotti P, Sfyroera G, Lambris JD. (2006). Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. Journal of Medicinal Chemistry 49: 4616-22. | | |
| Köhl J, Baelder R, Lewkowich IP, Pandey MK, Hawlisch H, Wang L, Best J, Herman NS, Sproles AA, Zwirner J, Whitsett JA, Gerard C, Sfyroera G, Lambris JD, Wills-Karp M. (2006). A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. The Journal of Clinical Investigation 116: 783-96. | | |
| Melillo D, Sfyroera G, De Santis R, Graziano R, Marino R, Lambris JD, Pinto MR. (2006). First identification of a chemotactic receptor in an invertebrate species: structural and functional characterization of Ciona intestinalis C3a receptor. Journal of immunology (Baltimore, Md.: 1950) 177: 4132-40. | | |
| Miwa T, Zhou L, Tudoran R, Lambris JD, Madaio MP, Nangaku M, Molina H, Song WC. (2006). DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity. Molecular Immunology 44: 139-46. | | |
| Nielsen EW, Waage C, Fure H, Brekke OL, Sfyroera G, Lambris JD, Mollnes TE. (2006). Effect of supraphysiologic levels of C1-inhibitor on the classical, lectin and alternative pathways of complement.Molecular Immunology 44: 1819-26. | | |
| Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J. (2006). Drusen complement components C3a and C5a promote choroidal neovascularization. Proceedings of the National Academy of Sciences of the United States of America 103: 2328-33. | | |
| Ritis K, Doumas M, Mastellos D, Micheli A, Giaglis S, Magotti P, Rafail S, Kartalis G, Sideras P, Lambris JD. (2006). A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways. Journal of Immunology 177: 4794-802. | | |
| Soulika AM, Holland MC, Sfyroera G, Sahu A, Lambris JD. (2006). Compstatin inhibits complement activation by binding to the beta-chain of complement factor 3. Molecular Immunology 43: 2023-9. | | |
| Bao L, Osawe I, Puri T, Lambris JD, Haas M, Quigg RJ. (2005). C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. European Journal of Immunology 35: 2496-506. | | |
| DeAngelis RA, Markiewski MM, Taub R, Lambris JD. (2005). A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology 42: 1148-57. | | |
| Lappegård KT, Riesenfeld J, Brekke OL, Bergseth G, Lambris JD, Mollnes TE. (2005). Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production. The Annals of Thoracic Surgery 79: 917-23. | | |
| Li S, Boackle SA, Holers VM, Lambris JD, Blatteis CM. (2005). Complement component c5a is integral to the febrile response of mice to lipopolysaccharide. Neuroimmunomodulation 12: 67-80. | | |
| Liu J, Miwa T, Hilliard B, Chen Y, Lambris JD, Wells AD, Song WC. (2005). The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. The Journal of Experimental Medicine 201: 567-77. | | |
| Mallik B, Katragadda M, Spruce LA, Carafides C, Tsokos CG, Morikis D, Lambris JD. (2005). Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. Journal of Medicinal Chemistry 48: 274-86. | | |
| Pappas IS, Lambris JD, Vizirianakis IS, Winters MS, Tsiftsoglou AS. (2005). Mechanisms of action of differentiation inducers: detection of inducer binding protein(s) in murine erythroleukemia cells. Oncology Research 15: 21-37. | | |
| Sfyroera G, Katragadda M, Morikis D, Isaacs SN, Lambris JD. (2005). Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins. Journal of Immunology 174: 2143-51. | | |
| Strey CW, Winters MS, Markiewski MM, Lambris JD. (2005). Partial hepatectomy induced liver proteome changes in mice. Proteomics 5: 318-25. | | |
| Winters MS, Spellman DS, Lambris JD. (2005). Solvent accessibility of native and hydrolyzed human complement protein 3 analyzed by hydrogen/deuterium exchange and mass spectrometry. Journal of Immunology 174: 3469-74. | | |
| Andersson J, Ekdahl KN, Lambris JD, Nilsson B. (2004). Binding of C3 fragments on top of adsorbed plasma proteins during complement activation on a model biomaterial surface. Biomaterials 26: 1477-85. | | |
| Bell E, Shamim M, Whitbeck JC, Sfyroera G, Lambris JD, Isaacs SN. (2004). Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin. Virology 325: 425-31. | | |
| Katragadda M, Morikis D, Lambris JD. (2004). Thermodynamic studies on the interaction of the third complement component and its inhibitor, compstatin. The Journal of Biological Chemistry 279: 54987-95. | | |
| Kim AH, Dimitriou ID, Holland MC, Mastellos D, Mueller YM, Altman JD, Lambris JD, Katsikis PD. (2004). Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses. Journal of Immunology 173: 2524-9. | | |
| Klepeis JL, Floudas CA, Morikis D, Tsokos CG, Lambris JD. (2004). Design of peptide analogues with improves activity using a novel de Novo protein design approach. Industrial & Engineering Chemistry Research 43(14): 3817-3826. | | |
| Lappegård KT, Fung M, Bergseth G, Riesenfeld J, Lambris JD, Videm V, Mollnes TE. (2004). Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation. The Annals of Thoracic Surgery 77: 932-41. | | |
| Markiewski MM, Mastellos D, Tudoran R, DeAngelis RA, Strey CW, Franchini S, Wetsel RA, Erdei A, Lambris JD. (2004). C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury. Journal of Immunology 173: 747-54. | | |
| Mastellos D, Prechl J, László G, Papp K, Oláh E, Argyropoulos E, Franchini S, Tudoran R, Markiewski M, Lambris JD Erdei A. (2004). Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays. Molecular Immunology 40: 1213-21. | | |
| Morikis D, Lambris JD. (2004). The electrostatic nature of C3d-complement receptor 2 association. Journal of Immunology 172: 7537-47. | | |
| Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Shultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW. (2004). Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. American Journal of Respiratory and Critical Care Medicine 169: 726-32. | | |
| Sewell DL, Nacewicz B, Liu F, Macvilay S, Erdei A, Lambris JD, Sandor M, Fabry Z. (2004). Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. Journal of Neuroimmunology 155: 55-63. | | |
| Strey CW, Spellman D, Stieber A, Gonatas JO, Wang X, Lambris JD, Gonatas NK. (2004). Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. The American Journal of Pathology 165: 1701-18. | | |
| Fleming SD, Mastellos D, Karpel-Massler G, Shea-Donohue T, Lambris JD, Tsokos GC. (2003). C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury. Clinical Immunology 108: 263-73. | | |
| Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. (2003). Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. The Journal of Clinical Investigation 112: 1644-54. Additional Links: Erratum. | | |
| Holland MC, Lambris JD. (2003). A functional C5a anaphylatoxin receptor in a teleost species. Journal of Immunology 172: 349-55. | | |
| Isaacs SN, Argyropoulos E, Sfyroera G, Mohammad S, Lambris JD. (2003). Restoration of complement-enhanced neutralization of vaccinia virus virions by novel monoclonal antibodies raised against the vaccinia virus complement control protein. Journal of Virology 77: 8256-62. | | |
| Kazantzi A, Sfyroera G, Holland MC, Lambris JD, Zarkadis IK. (2003). Molecular cloning of the beta subunit of complement component eight of rainbow trout. Developmental and Comparative Immunology 27: 167-74. | | |
| Kimura Y, Madhavan M, Call MK, Santiago W, Tsonis PA, Lambris JD, Del Rio-Tsonis K. (2003). Expression of complement 3 and complement 5 in newt limb and lens regeneration. Journal of Immunology 170: 2331-9. Additional Links: In This Issue. | | |
| Klepeis JL, Floudas CA, Morikis D, Tsokos CG, Argyropoulos E, Spruce L, Lambris JD. (2003). Integrated computational and experimental approach for lead optimization and design of compstatin variants with improved activity. Journal of the American Chemical Society 125: 8422-3. Additional Links: Supplementary Information. | | |
| Mallik B, Lambris JD, Morikis D. (2003). Conformational interconversion in compstatin probed with molecular dynamics simulations. Proteins 53: 130-41. | | |
| Mullick J, Bernet J, Singh AK, Lambris JD, Sahu A. (2003). Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) open reading frame 4 protein (kaposica) is a functional homolog of complement control proteins. Journal of Virology 77: 3878-81. | | |
| Pinto MR, Chinnici CM, Kimura Y, Melillo D, Marino R, Spruce LA, De Santis R, Parrinello N, Lambris JD. (2003). CiC3-1a-mediated chemotaxis in the deuterostome invertebrate Ciona intestinalis (Urochordata). Journal of Immunology 171: 5521-8. | | |
| Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S, Glodek A, Honczarenko M, Spruce LA, Janowska-Wieczorek A, Lambris JD, Ratajczak MZ. (2003). Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood 101: 3784-93. | | |
| Sahu A, Morikis D, Lambris JD. (2003). Compstatin, a peptide inhibitor of complement, exhibits species-specific binding to complement component C3. Molecular Immunology 39: 557-66. | | |
| Soulika AM, Morikis D, Sarrias MR, Roy M, Spruce LA, Sahu A, Lambris JD. (2003). Studies of structure-activity relations of complement inhibitor compstatin. Journal of Immunology 171: 1881-90. | | |
| Strey CW, Markiewski M, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE, Lambris JD.(2003). The proinflammatory mediators C3a and C5a are essential for liver regeneration. The Journal of Experimental Medicine 198: 913-23. | | |
| Suresh M, Molina H, Salvato MS, Mastellos D, Lambris JD, Sandor M. (2003). Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection. Journal of Immunology 170: 788-94. | | |
| Barilla-LaBarca ML, Liszewski MK, Lambris JD, Hourcade D, Atkinson JP. (2002). Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. Journal of Immunology 168: 6298-304. | | |
| Huber-Lang MS, Riedeman NC, Sarma JV, Younkin EM, McGuire SR, Laudes IJ, Lu KT, Guo RF, Neff TA, Padgaonkar VA, Lambris JD, Spruce L, Mastellos D, Zetoune FS, Ward PA. (2002). Protection of innate immunity by C5aR antagonist in septic mice. The FASEB Journal 16: 1567-74. | | |
| Laudes IJ, Chu JC, Huber-Lang M, Guo RF, Riedemann NC, Sarma JV, Mahdi F, Murphy HS, Speyer C, Lu KT, Lambris JD, Zetoune FS, Ward PA. (2002). Expression and function of C5a receptor in mouse microvascular endothelial cells. Journal of Immunology 169: 5962-70. | | |
| Lubinski JM, Jiang M, Hook L, Chang Y, Sarver C, Mastellos D, Lambris JD, Cohen GH, Eisenberg RJ, Friedman HM. (2002). Herpes simplex virus type 1 evades the effects of antibody and complement in vivo. Journal of Virology 76: 9232-41. | | |
| Marino R, Kimura Y, De Santis R, Lambris JD, Pinto MR. (2002). Complement in urochordates: cloning and characterization of two C3-like genes in the ascidian Ciona intestinalis. Immunogenetics 53: 1055-64. | | |
| Molina H, Miwa T, Zhou L, Hilliard B, Mastellos D, Maldonado MA, Lambris JD, Song WC.(2002). Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor. Blood 100: 4544-9. | | |
| Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappegård KT, Köhl J, Lambris JD. (2002). Essential role of the C5a receptor in E. coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood 100: 1869-77. | | |
| Morikis D, Roy M, Sahu A, Troganis A, Jennings PA, Tsokos GC, Lambris JD. (2002). The structural basis of compstatin activity examined by structure-function-based design of peptide analogs and NMR. The Journal of Biological Chemistry 277: 14942-53. Additional Links: Supplementary Information. | | |
| Riedemann NC, Guo RF, Neff TA, Laudes IJ, Keller KA, Sarma VJ, Markiewski MM, Mastellos D, Strey CW, Pierson CL, Lambris JD, Zetoune FS, Ward PA. (2002). Increased C5a receptor expression in sepsis. The Journal of Clinical Investigation 110: 101-8. | | |
| Riedemann NC, Neff TA, Guo RF, Bernacki KD, Laudes IJ, Sarma JV, Lambris JD, Ward PA. (2002). Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression Journal of Immunology 170: 503-7. | | |
| Rux AH, Lou H, Lambris JD, Friedman HM, Eisenberg RJ, Cohen GH. (2002). Kinetic analysis of glycoprotein C of herpes simplex virus types 1 and 2 binding to heparin, heparan sulfate, and complement component C3b. Virology 294: 324-32. | | |
| Sølvik UO, Haraldsen G, Fiane AE, Boretti E, Lambris JD, Fung M, Thorsby E, Mollnes TE. (2002). Human serum-induced expression of E-selectin on porcine aortic endothelial cells in vitro is totally complement mediated. Transplantation 72: 1967-73. | | |
| Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E. (2002). Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proceedings of the National Academy of Sciences of the United States of America 99: 10837-42. | | |
| Franchini S, Zarkadis IK, Sfyroera G, Sahu A, Moore WT, Mastellos D, LaPatra SE, Lambris JD. (2001). Cloning and purification of the rainbow trout fifth component of complement (C5). Developmental and Comparative Immunology 25: 419-30. | | |
| Guthridge JM, Rakstang JK, Young KA, Hinshelwood J, Aslam M, Robertson A, Gipson MG, Sarrias MR, Moore WT, Meagher M, Karp D, Lambris JD, Perkins SJ, Holers VM. (2001). Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg. Biochemistry 40: 5931-41. | | |
| Guthridge JM, Young K, Gipson MG, Sarrias MR, Szakonyi G, Chen XS, Malaspina A, Donoghue E, James JA, Lambris JD, Moir SA, Perkins SJ, Holers VM. (2001). Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface. Journal of Immunology 167: 5758-66. | | |
| Mastellos D, Papadimitriou JC, Franchini S, Tsonis PA, Lambris JD. (2001). A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. Journal of Immunology 166: 2479-86. | | |
| Sarrias MR, Franchini S, Canziani G, Argyropoulos E, Moore WT, Sahu A, Lambris JD. (2001). Kinetic analysis of the interactions of complement receptor 2 (CR2, CD21) with its ligands C3d, iC3b, and the EBV glycoprotein gp350/220. Journal of Immunology 167: 1490-9. Additional Links: Biacore PDF. | | |
| Sarrias MR, Whitbeck JC, Rooney I, Ware CF, Eisenberg RJ, Cohen GH, Lambris JD. (2001). The three HveA receptor ligands, gD, LT-alpha and LIGHT bind to distinct sites on HveA. Molecular Immunology 37: 665-73. | | |
| Vasta GR, Lambris JD. (2001). Innate immunity in the Aegean: ancient pathways for today's survival. Developmental and Comparative Immunology 26: 217-25. | | |
| Fiane AE, Videm V, Lambris JD, Geiran OR, Svennevig JL, Mollnes TE. (2000). Modulation of fluid-phase complement activation inhibits hyperacute rejection in a porcine-to-human xenograft model. Transplantation Proceedings 32: 899-900. | | |
| Friedman HM, Wang L, Pangburn MK, Lambris JD, Lubinski J. (2000). Novel mechanism of antibody-independent complement neutralization of herpes simplex virus type 1. Journal of Immunology 165: 4528-36. | | |
| Lubinski J, Wang L, Mastellos D, Sahu A, Lambris JD, Friedman HM. (2000). In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC. The Journal of Experimental Medicine 190: 1637-46. | | |
| Sahu A, Soulika AM, Morikis D, Spruce L, Moore WT, Lambris JD. (2000). Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin. Journal of Immunology 165: 2491-9. | | |
| Soulika AM, Khan MM, Hattori T, Bowen FW, Richardson BA, Hack CE, Sahu A, Edmunds LH, Lambris JD. (2000). Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clinical Immunology 96: 212-21. | | |
| Zarkadis IK, Sarrias MR, Sfyroera G, Sunyer JO, Lambris JD. (2000). Cloning and structure of three rainbow trout C3 molecules: a plausible explanation for their functional diversity. Developmental and Comparative Immunology 25: 11-24. | | |
| Del Rio-Tsonis K, Tsonis PA, Zarkadis IK, Tsagas AG, Lambris JD. (1999). Expression of the third component of complement, C3, in regenerating limb blastema cells of urodeles. Journal of Immunology 161: 6819-24. | | |
| Fiane AE, Mollnes TE, Videm V, Hovig T, Høgåsen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD. (1999). Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6: 52-65. | | |
| Fiane AE, Mollnes TE, Videm V, Hovig T, Høgåsen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD. (1999). Prolongation of ex vivo-perfused pig xenograft survival by the complement inhibitor Compstatin. Transplantation Proceedings 31: 934-5. | | |
| Klepeis JL, Floudas CA, Morikis D, Lambris JD. (1999). Predicting peptide structures using NMR data and deterministic global optimization. Journal of Computational Chemistry 20: 1354-1370. | | |
| Lambris JD, Reid KB, Volanakis JE. (1999). The evolution, structure, biology and pathophysiology of complement. Immunology Today 20: 207-11. | | |
| Noorchashm H, Moore DJ, Lieu YK, Noorchashm N, Schlachterman A, Song HK, Lambris JD, Barker CF, Naji A. (1999). Contribution of the innate immune system to autoimmune diabetes: A role for the CR1/CR2 complement receptors. Cellular Immunology 195: 75-79. | | |
| Sarrias MR, Whitbeck JC, Rooney I, Spruce L, Kay BK, Montgomery RI, Spear PG, Ware CF, Eisenberg RJ, Cohen GH, Lambris JD. (1999). Inhibition of herpes simplex virus gD and lymphotoxin-alpha binding to HveA by peptide antagonists. Journal of Virology 73: 5681-7. | | |
| Sun X, Funk CD, Deng C, Sahu A, Lambris JD, Song WC. (1999). Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Proceedings of the National Academy of Sciences of the United States of America 96: 628-33. | | |
| Al-Sharif WZ, Sunyer JO, Lambris JD, Smith LC. (1998). Sea urchin coelomocytes specifically express a homologue of the complement component C3. Journal of Immunology 160: 2983-97. | | |
| Krummenacher C, Nicola AV, Whitbeck JC, Lou H, Hou W, Lambris JD, Geraghty RJ, Spear PG, Cohen GH, Eisenberg RJ. (1998). Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry. Journal of Virology 72: 7064-74. | | |
| Lubinski JM, Wang L, Soulika AM, Burger R, Wetsel RA, Colten H, Cohen GH, Eisenberg RJ, Lambris JD, Friedman HM. (1998). Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo. Journal of Virology 72: 8257-63. | | |
| Morikis D, Assa-Munt N, Sahu A, Lambris JD. (1998). Solution structure of Compstatin, a potent complement inhibitor. Protein Science 7: 619-27. | | |
| Nilsson B, Larsson R, Hong J, Elgue G, Ekdahl KN, Sahu A, Lambris JD. (1998). Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulation. Blood 92: 1661-7. | | |
| Peng T, Ponce de Leon M, Novotny MJ, Jiang H, Lambris JD, Dubin G, Spear PG, Cohen GH, Eisenberg RJ. (1998). Structural and antigenic analysis of a truncated form of the herpes simplex virus glycoprotein gH-gL complex. Journal of Virology 72: 6092-103. | | |
| Sahu A, Isaacs SN, Soulika AM, Lambris JD. (1998). Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway. Journal of Immunology 160: 5596-604. | | |
| Sunyer JO, Zarkadis I, Sarrias MR, Hansen JD, Lambris JD. (1998). Cloning, structure, and function of two rainbow trout Bf molecules. Journal of Immunology 161: 4106-14. | | |
| Tolnay M, Lambris JD, Tsokos GC. (1998). Transcriptional regulation of the complement receptor 2 gene: role of a heterogeneous nuclear ribonucleoprotein. Journal of Immunology 159: 5492-501. | | |
| Kostavasili I, Sahu A, Friedman HM, Eisenberg RJ, Cohen GH, Lambris JD. (1997). Mechanism of complement inactivation by glycoprotein C of herpes simplex virus. Journal of Immunology 158: 1763-71. | | |
| Sunyer JO, Tort L, Lambris JD. (1997). Structural C3 diversity in fish: characterization of five forms of C3 in the diploid fish Sparus aurata. Journal of Immunology 158: 2813-21. | | |
| Sunyer JO, Tort L, Lambris JD. (1997). Diversity of the third form of complement, C3, in fish: functional characterization of five forms of C3 in the diploid fish Sparus aurata. The Biochemical Journal 326 (Pt 3): 877-81. | | |
| Whitbeck JC, Peng C, Lou H, Xu R, Willis SH, Ponce de Leon M, Peng T, Nicola AV, Montgomery RI, Warner MS, Soulika AM, Spruce LA, Moore WT, Lambris JD, Spear PG, Cohen GH, Eisenberg RJ. (1997). Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry. Journal of Virology 71: 6083-93. | | |
| Zarkadis IK, Omigbodun A, Forson A, Ziolkiewicz P, Kinoshita T, Lambris JD, Coutifaris C. (1997). Differentiation-dependent changes in human trophoblast expression of decay-accelerating factor are modulated by 3',5' cyclic adenosine monophosphate. Journal of the Society for Gynecologic Investigation 4: 47-53. | | |
| Friedman HM, Wang L, Fishman NO, Lambris JD, Eisenberg RJ, Cohen GH, Lubinski J. (1996). Immune evasion properties of herpes simplex virus type 1 glycoprotein gC. Journal of Virology 70: 4253-60. | | |
| Kozlowski LM, Soulika AM, Silverman GJ, Lambris JD, Levinson AI. (1996). Complement activation by a B cell superantigen. Journal of Immunology 157: 1200-6. | | |
| Lambris JD, Lao Z, Oglesby TJ, Atkinson JP, Hack CE, Becherer JD. (1996). Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component. Journal of Immunology 156: 4821-32. | | |
| Moore DJ, Lambris JD. (1996). Mass spectrometric analysis of the activation products of the third component of complement. Techniques in Protein Chemistry VII Academic Press 7: 81-91. | | |
| Rux AH, Moore WT, Lambris JD, Abrams WR, Peng C, Friedman HM, Cohen GH, Eisenberg RJ. (1996). Disulfide bond structure determination and biochemical analysis of glycoprotein C from herpes simplex virus. Journal of Virology 70: 5455-65. | | |
| Sahu A, Kay BK, Lambris JD. (1996). Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. Journal of Immunology 157: 884-91. | | |
| Stavridi ES, O'Malley K, Lukacs CM, Moore WT, Lambris JD, Christianson DW, Rubin H, Cooperman BS. (1996). Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis. Biochemistry 35: 10608-15. | | |
| Sunyer JO, Zarkadis IK, Sahu A, Lambris JD. (1996). Multiple forms of complement C3 in trout that differ in binding to complement activators. Proceedings of the National Academy of Sciences of the United States of America 93: 8546-51. | | |
| Kozlowski LM, Lambris JD, Levinson AI. (1995). Effect of a putative B cell superantigen on complement. Annals of the New York Academy of Sciences 764: 356-8. | | |
| Lambris JD, Pappas J, Mavroidis M, Wang Y, Manzone H, Schwager J, Du Pasquier L, Silibovsky R, Swager J [corrected to Schwager J]. (1995). The third component of Xenopus complement: cDNA cloning, structural and functional analysis, and evidence for an alternate C3 transcript. European Journal of Immunology 25: 572-8. | | |
| Mavroidis M, Sunyer JO, Lambris JD. (1995). Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family. Journal of Immunology 154: 2164-74. | | |
| Hasty LA, Brockman WW, Lambris JD, Lyttle CR. (1994). Hormonal regulation of complement factor B in human endometrium. American Journal of Reproductive Immunology 30: 63-7. | | |
| Hasty LA, Lambris JD, Lessey BA, Pruksananonda K, Lyttle CR. (1994). Hormonal regulation of complement components and receptors throughout the menstrual cycle. American Journal of Obstetrics and Gynecology 170: 168-75. | | |
| Hedrick JA, Lao Z, Lipps SG, Wang Y, Todd SC, Lambris JD, Tsoukas CD. (1994). Characterization of a 70-kDa, EBV gp350/220-binding protein on HSB-2 T cells. Journal of Immunology 153: 4418-26. | | |
| Hung SL, Peng C, Kostavasili I, Friedman HM, Lambris JD, Eisenberg RJ, Cohen GH. (1994). The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway. Virology 203: 299-312. | | |
| Lambris JD, Lao Z, Pang J, Alsenz J. (1994). Third component of trout complement. cDNA cloning and conservation of functional sites. Journal of Immunology 151: 6123-34. | | |
| Lambris JD, Mavroidis M, Pappas J, Lao Z, Wang Y. (1994). Phylogeny of the third complement component, C3, and conservation of C3-ligand interactions. Annals of the New York Academy of Sciences 712: 354-7. | | |
| Lao Z, Wang Y, Mavroidis M, Kostavasili I, Lambris JD. (1994). Overexpression, purification, and characterization of third component of complement. Journal of Immunological Methods 176: 127-39. | | |
| Smith CI, Baskin B, Humire-Greiff P, Zhou JN, Olsson PG, Maniar HS, Kjellén P, Lambris JD, Christensson B, Hammarström L. (1994). Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells. Journal of Immunology 152: 557-65. | | |
| Sinha SK, Todd SC, Hedrick JA, Speiser CL, Lambris JD, Tsoukas CD. (1993). Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript. Journal of Immunology 150: 5311-20. | | |
| Alsenz J, Avila D, Huemer HP, Esparza I, Becherer JD, Kinoshita T, Wang Y, Oppermann S, Lambris JD. (1992). Phylogeny of the third component of complement, C3: analysis of the conservation of human CR1, CR2, H, and B binding sites, concanavalin A binding sites, and thiolester bond in the C3 from different species. Developmental and Comparative Immunology 16: 63-76. | | |
| Becherer JD, Alsenz J, Esparza I, Hack CE, Lambris JD. (1992). Segment spanning residues 727-768 of the complement C3 sequence contains a neoantigenic site and accommodates the binding of CR1, factor H, and factor B. Biochemistry 31: 1787-94. | | |
| Hedrick JA, Watry D, Speiser C, O'Donnell P, Lambris JD, Tsoukas CD. (1992). Interaction between Epstein-Barr virus and a T cell line (HSB-2) via a receptor phenotypically distinct from complement receptor type 2. European Journal of Immunology 22: 1123-31. | | |
| Kaufman J, Andersen R, Avila D, Engberg J, Lambris J, Salomonsen J, Welinder K, Skjødt K. (1992). Different features of the MHC class I heterodimer have evolved at different rates. Chicken B-F and beta 2-microglobulin sequences reveal invariant surface residues. Journal of Immunology 148: 1532-46. | | |
| Nilsson B, Grossberger D, Nilsson Ekdahl K, Riegert P, Becherer DJ, Nilsson UR, Lambris JD. (1992). Conformational differences between surface-bound and fluid-phase complement-component-C3 fragments. Epitope mapping by cDNA expression. The Biochemical Journal 282 ( Pt 3): 715-21 . | | |
| Esparza I, Becherer JD, Alsenz J, De la Hera A, Lao Z, Tsoukas CD, Lambris JD. (1991). Evidence for multiple sites of interaction in C3 for complement receptor type 2 (C3d/EBV receptor, CD21). European Journal of Immunology 21: 2829-38. | | |
| Møller LB, Kaufman J, Verland S, Salomonsen J, Avila D, Lambris JD, Skjødt K. (1991). Variations in the cytoplasmic region account for the heterogeneity of the chicken MHC class I (B-F) molecules. Immunogenetics 34: 110-20. | | |
| Watry D, Hedrick JA, Siervo S, Rhodes G, Lamberti JJ, Lambris JD, Tsoukas CD. (1991). Infection of human thymocytes by Epstein-Barr virus. The Journal of Experimental Medicine 173: 971-80. | | |
| Avila D, Lambris JD. (1990). Isolation and characterization of the third complement component of axolotl (Ambystoma mexicanum). Comparative Biochemistry and Physiology B., Comparative Biochemistry 95: 839-45. | | |
| Nilsson B, Nilsson Ekdahl K, Avila D, Nilsson UR, Lambris JD. (1990). Neoantigens in complement component C3 as detected by monoclonal antibodies. Mapping of the recognized epitopes by synthetic peptides. The Biochemical Journal 268: 55-61. | | |
| Tsokos GC, Lambris JD, Finkelman FD, Anastassiou ED, June CH. (1990). Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration. Journal of Immunology 144: 1640-5. | | |
| Alsenz J, Lambris JD, Bork K, Loos M. (1989). Acquired C1 inhibitor (C1-INH) deficiency type II. Replacement therapy with C1-INH and analysis of patients' C1-INH and anti-C1-INH autoantibodies. The Journal of Clinical Investigation 83: 1794-9. | | |
| Baxevanis CN, Reclos GJ, Servis C, Anastasopoulos E, Arsenis P, Katsiyiannis A, Matikas N, Lambris JD, Papamichail M. (1989). Peptides of myelin basic protein stimulate T lymphocytes from patients with multiple sclerosis. Journal of Neuroimmunology 22: 23-30. | | |
| Bogen B, Lambris JD. (1989). Minimum length of an idiotypic peptide and a model for its binding to a major histocompatibility complex class II molecule. The EMBO Journal 8: 1947-52. | | |
| Dihanich M, van Tuinen E, Lambris JD, Marshallsay B. (1989). Accumulation of viruslike particles in a yeast mutant lacking a mitochondrial pore protein. Molecular and Cellular Biology 9: 1100-8. | | |
| Gisler RH, Schlienger C, Söderberg A, Ledermann F, Lambris JD. (1989). Functional maturation of murine B lymphocyte precursors--III. Soluble factors involved in the regulation of growth and differentiation. Molecular Immunology 25: 1113-27. | | |
| Grossberger D, Marcuz A, Du Pasquier L, Lambris JD. (1989). Conservation of structural and functional domains in complement component C3 of Xenopus and mammals. Proceedings of the National Academy of Sciences of the United States of America 86: 1323-7. | | |
| Huemer HP, Bröker M, Larcher C, Lambris JD, Dierich MP. (1989). The central segment of herpes simplex virus type 1 glycoprotein C (gC) is not involved in C3b binding: demonstration by using monoclonal antibodies and recombinant gC expressed in Escherichia coli. The Journal of General Virology 70 (Pt 6): 1571-8. | | |
| Lassila O, Lambris JD, Gisler RH. (1989). A role for Lys-His-Gly-NH2 in avian and murine B cell development. Cellular Immunology 122: 319-28. | | |
| Pluschke G, Bordmann G, Daoudaki ME, Lambris JD, Achtman M, Neibert M. (1989). Isolation of rat IgM to IgG hybridoma isotype switch variants and analysis of the efficiency of rat Ig in complement activation. European Journal of Immunology 19: 131-5. | | |
| Servis C, Lambris JD. (1989). C3 synthetic peptides support growth of human CR2-positive lymphoblastoid B cells. Journal of Immunology 142: 2207-12. | | |
| Becherer JD, Lambris JD. (1988). Identification of the C3b receptor-binding domain in third component of complement. The Journal of Biological Chemistry 263: 14586-91. | | |
| Daoudaki ME, Becherer JD, Lambris JD. (1988). A 34-amino acid peptide of the third component of complement mediates properdin binding. Journal of Immunology 140: 1577-80. | | |
| Frei Y, Lambris JD, Stockinger B. (1988). Generation of a monoclonal antibody to mouse C5 application in an ELISA assay for detection of anti-C5 antibodies. Molecular and Cellular Probes 1: 141-9. | | |
| Lambris JD, Avila D, Becherer JD, Müller-Eberhard HJ. (1988). A discontinuous factor H binding site in the third component of complement as delineated by synthetic peptides. The Journal of Biological Chemistry 263: 12147-50. | | |
| Reclos JG, Baxevanis CN, Servis K, Arsenis P, Katsiyiannis A, Matikas N, Lambris JD, Papamichail M. (1988). Proliferative responses of T lymphocytes from patients with Multiple Sclerosis to human myelin basic protein peptides. In Trends in European Multiple Sclerosis research. Elsevier Science Pub 211-215. | | |
| Tsoukas CD, Lambris JD. (1988). Expression of CR2/EBV receptors on human thymocytes detected by monoclonal antibodies. European Journal of Immunology 18: 1299-302. | | |
| Tsokos GC, Inghirami G, Lambris JD. (1987). Regulation of human cytotoxic responses by complement: C3, C3b and C3d preparations enhance human allogeneic cytotoxic responses. Journal of Immunopharmacology 8: 529-41. | | |
| Alsenz J, Schulz TF, Lambris JD, Sim RB, Dierich MP. (1986). Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H. The Biochemical Journal 232: 841-50. | | |
| Hirani S, Lambris JD, Müller-Eberhard HJ. (1986). Structural analysis of the asparagine-linked oligosaccharides of human complement component C3. The Biochemical Journal 233: 613-6. | | |
| Inghirami G, Lambris JD, Tsokos GC. (1986). Complement receptors (CR) and cytotoxic responses: monoclonal antibodies directed against CR1 and CR3 inhibit the generation of human allospecific and virus specific cytotoxic cells in vitro. Journal of Immunopharmacology 8: 75-88. | | |
| Tsonis PA, Lambris JD. (1986). Similarities between a conserved sequence element of homoeo boxes and other genes. FEBS letters 194: 263-6. | | |
| Aguado MT, Lambris JD, Tsokos GC, Burger R, Bitter-Suermann D, Tamerius JD, Dixon FJ, Theofilopoulos AN. (1985). Monoclonal antibodies against complement 3 neoantigens for detection of immune complexes and complement activation. Relationship between immune complex levels, state of C3, and numbers of receptors for C3b. The Journal of Clinical Investigation 76: 1418-26. | | |
| Alsenz J, Lambris JD, Schulz TF, Dierich MP. (1985). Localization of the complement component C3b binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H. The Biochemical Journal 224: 389-98. | | |
| Hirani S, Lambris JD, Müller-Eberhard HJ. (1985). Localization of the conglutinin binding site on the third component of human complement. Journal of Immunology 134: 1105-9. | | |
| Lambris JD, Hirani S, Ganu VS, Becherer D, Müller-Eberhard HJ. (1985). Synthetic peptides predicted from the nucleotide sequence of complement C3 bind to C3d receptor and monoclonal antibody 130. Advances in Gene Technology: Molecular Biology of the Immune System 2: 213-214. | | |
| Pryzwansky KB, Lambris JD, MacRae EK, Schwab JH. (1985). Opsonized streptococcal cell walls cross-link human leukocytes and erythrocytes by complement receptors. Infection and Immunity 49: 550-6. | | |
| Schulz TF, Scharfenberger H, Lambris JD, Rieber P, Riethmüller G, Dierich MP. (1985). Antigenic relationship between the alpha-chain of C3, a leucocyte-surface antigen involved in the activation of phagocytic cells, and a 50,000 MW B-cell antigen. Immunology 54: 791-800. | | |
| Tsokos GC, Inghirami G, Tsoukas CD, Balow JE, Lambris JD. (1985). Regulation of immunoglobulin secretion by factor H of human complement. Immunology 55: 419-26. | | |
| Lambris JD, Alsenz J, Schulz TF, Dierich MP. (1984). Mapping of the properdin-binding site in the third component of complement. The Biochemical Journal 217: 323-6. | | |
| Lambris JD, Müller-Eberhard HJ. (1984). Isolation and characterization of a 33,000-dalton fragment of complement Factor B with catalytic and C3b binding activity. The Journal of Biological Chemistry 259: 12685-90. | | |
| Lambris JD, Scheiner O, Schulz TF, Alsenz J, Dierich MP. (1984). Coupling of C3b to erythrocytes by disulfide bond formation: preparation of EC3b for hemolytic and complement receptor assays.Journal of Immunological Methods 65: 277-83. | | |
| Schulz TF, Scheiner O, Alsenz J, Lambris JD, Dierich MP. (1984). Use of monoclonal antibodies against factor H to investigate the role of a membrane-associated protein antigenically related to H in C3b-receptor function. Journal of Immunology 132: 392-8. | | |
| Tsoukas CD, Lambris J, Lotz M, Valentine MA, Vaughan JH, Carson DA. (1984). Lymphocyte mitogenesis induced by monoclonal antibodies to the T3 complex. Differential modulation by human IgG. Cellular Immunology 89: 66-74. | | |
| Hutt-Fletcher LM, Fowler E, Lambris JD, Feighny RJ, Simmons JG, Ross GD. (1983). Studies of the Epstein Barr virus receptor found on Raji cells. II. A comparison of lymphocyte binding sites for Epstein Barr virus and C3d. Journal of Immunology 130: 1309-12. | | |
| Pryzwansky KB, MacRae EK, Lambris JD. (1983). Capping of complement receptors on human neutrophils induced by group A streptococcal cell walls. Journal of Immunology 130: 1674-7. | | |
| Ross GD, Newman SL, Lambris JD, Devery-Pocius JE, Cain JA, Lachmann PJ. (1983). Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 fragments for factors B and H, complement receptors, and bovine conglutinin. The Journal of Experimental Medicine 158: 334-52. | | |
| Scheiner O, Schulz TF, Schmid HU, Lambris JD, Alsenz J, Dierich MP. (1983). Importance of factors H and I for the adherence of C3b-coated erythrocytes to cells. Immunobiology 165: 211-24. | | |
| Tsiganos CP, Stamatiadou M, Lambris J, Papamichail M. (1983). Detection of cartilage proteoglycan-related antigens on the surface of 3T3 cells. Progress in Clinical and Biological Research 102 Pt. A: 447-54. | | |
| Lambris J, Papamichail M, Ioannidis C, Dimitracopoulos G. (1982). Activation of the alternative pathway of human complement by the extracellular slime glycolipoprotein of Pseudomonas aeruginosa.The Journal of Infectious Diseases 145: 78-82. | | |
| Lambris JD, Allen JB, Schwab JH. (1982). In vivo changes in complement induced with peptidoglycan-polysaccharide polymers from streptococcal cell walls. Infection and Immunity 35: 377-80. | | |
| Lambris JD, Ross GD. (1982). Assay of membrane complement receptors (CR1 and CR2) with C3b- and C3d-coated fluorescent microspheres. Journal of Immunology 128: 186-9. | | |
| Lambris JD, Ross GD. (1982). Characterization of the lymphocyte membrane receptor for factor H (beta 1H-globulin) with an antibody to anti-factor H idiotype. The Journal of Experimental Medicine 155: 1400-11. | | |
| Ross GD, Lambris JD. (1982). Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes. The Journal of Experimental Medicine 155: 96-110. | | |
| Ross GD, Lambris JD, Cain JA, Newman SL. (1982). Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity. Journal of Immunology 129: 2051-60. | | |
| Dobson NJ, Lambris JD, Ross GD. (1981). Characteristics of isolated erythrocyte complement receptor type one (CR1, C4b-C3b receptor) and CR1-specific antibodies. Journal of Immunology 126: 693-8. | | |
| Lambris JD, Dobson NJ, Ross GD. (1981). Isolation of lymphocyte membrane complement receptor type two (the C3d receptor) and preparation of receptor-specific antibody. Proceedings of the National Academy of Sciences of the United States of America 78: 1828-32. | | |
| Lambris JD, Dobson NJ, Ross GD. (1981). Release of endogenous C3b inactivator from lymphocytes in response to triggering membrane receptors for beta 1H globulin. The Journal of Experimental Medicine 152: 1625-44. | | |
| Lambris J, Papamichail M. (1980). A method for analysing lymphocyte surface antigens. Journal of Immunological Methods 34: 287-93. | | |
| Lambris J, Papavassiliou J, Dimitracopoulos G. (1980). Protein component of Pseudomonas aeruginosa slime glycolipoprotein in relation to laboratory-induced resistance to gentamicin. Canadian Journal of Microbiology 26: 852-853. | | |
| Lambris J, Papamichail M, Fessas P. (1979). Fluorescent labelling of proteins of lymphocyte plasma membranes. Journal of Immunological Methods 27: 55-9. | | |