Grants Received

2014-2019Complement in inflammatory diseases: Mechanisms & therapeutic modulation
NIH P01-AI068730
Total Support $10,000,000
(Priority Score 1)
2013-2017Disarming the intravascular innate immune response to improve modalities for chronic kidney disease treatment
DIREKT (FP7-HEALTH-2013-INNOVATION-1)
EUROPEAN GRANT
PI: B Nilsson; Co-PI: JD Lambris
Total Support for JD Lambris: $1,000,000
2013-2017Structural analysis of the third component of complement
NIH AI 30040
Total Support $1,471,833
2012-2016Novel mechanisms and Complement-ary therapy in periodontitis
NIH DE021685
PI: G Hajishengallis; Co-PI: JD Lambris
Total Support: $2,000,000
2012-2015A novel approach for assessing dynamic events in the human complement system
NIH R21-AI097805
PI: D. Ricklin; Co-PI: John D. Lambris
Total Support: $676,800
2011-2016Complement inhibition as sepsis therapy
NIH 1-R01-GM-097747-01
M.P.I. JD Lambris & F Lupu (University of Oklahoma)
Total Support $2,084,220
2011-2015Complement in AMD: Mechanisms and therapeutic intervention
NIH 5-R01-EY-020633
2012-2013Complement based therapies to periodontal disease
ITMAT University of Pennsylvania
UL1RR024134
2011-2012A novel iron-amyloid beta pathway for complement activation quantified with a new high sensitivity assay
Beckman Foundation (Arnold and Mabel)
(P.I. Dunaief, Joshua L University of Pennsylvania)
2007-2012Complement in cell proliferation and injury - therapeutic interventions
NIH, effort 40%
Total Support $7,500,000
(Priority Score 154)
2007-2012Complement mediated neuronal injury in stroke
NIH (P.I.Connely, Columbia University), effort 5%
Total Support for JDL $634,000.
2007-2012Design of novel complement inhibitors
NIH
Total Support $1,260,000
(Priority Score 127, 7.7 Percentile)
2007-2012Structural functional analysis of staphylococcal complement inhibitors
NIH
(P.I.Geisbrecht, B University of Missouri-Kansas City)
Total Support for JDL $780,000
(9.9 Percentile)
2007-2012Thermodynamic and structural studies on formation of the C3 convertase
NIH, effort 10%
Total Support $1,981,250
(2.9 Percentile)
2006-2012Structural and functional analysis of C3
NIH AI 30040
Total Support $1,631,875
(2 Percentile)
2005-2010Biomaterial-induced complement activation
NIH
Total Support $1,064,213
(12.7 Percentile)
2005-2010The role of complement in ovarian cancer
NIH
Total Support $1,585,000
(3.6 Percentile)
2004-2008Computer aided design of complement therapeutics
NIH R24GM069736
Total Support $1,871,000
(Priority Score 127, 7.7 Percentile)
2004-2007In Silico De Novo protein design: A Dynamically Data Driven, (DDDAS), Computational and experimental framework
ITR: Collaborative Research: (ASE+NHS+EVS)-(sim+dmc+int) NSF 0426691
(P.I.Floudas, C. Princeton), effort 10%
Total Support for JDL $370,000.
2003-2007Defence against biowarfare and emerging infection agents. Sub project 3 of poxvirus project: Identify the targets of VIG using proteomics approach
NIH U54 AI057168-01, effort 10%
Total Support $720,000
2001-2007Structural-functional analysis of Compstatin
NIH GM-62134
Total Support $1,300,000
(9.9 Percentile)
2001-2006Vaccinia B5R protein in spread immune evasion, vaccines
NIH
(P.I.Isaacs, S), effort 5%
Total Support for JDL $395,500
2000-2006Structural and functional analysis of C3
NIH AI 30040
Total Support $1,193,000
2000-2004Poxvirus SCR-containing proteins as therapeutic targets
NIH
(P.I.Isaacs, S), effort 5%
Total Support for JDL $521,500
1999Purchase of a MALDI/MS system
NIH
Total Support $250,000
1998-2003Role of B cells in autoimmune diabetes
NIH
(P.I.Naji, A), effort 5%
Total Support for JDL $324,320
1998-2003Studies on complement diversity and evolution
NIH GM-56698, effort 10%
Total Support $1,231,877
1997-2003Pathogenesis of persistent viral injury to the CNS-Sub: Early events in herpes simple virus entry into cells of neural origin
NIH
(P.I.Eisenberg, R), effort 5%
Total Support for JDL $160,000
1997-2002Cellular interactions of plasma proteins
NIH P-10-HL-56914
(P.I.Walsh, P), effort 10%
Total Support for JDL $688,000
1997-2002Early events in Herpes Simplex Virus Entry
NIH
(P.I.Eisenberg, R), effort 5%
Total Support for JDL $159,000
1997Purchase of an HPLC system
Research Foundation of the University of Pennsylvania
Total Support $14,500
1996-2001Virus and immune injury to vessel wall cells
NIH 5 RO1 HL28220, effort 10%
Total Support $625,770
1995-1999CSVTCG-Specific thrombospondin receptor in breast cancer
NIH CA65675
(P.I.Tuszynski, G), effort 10%
Total Support for JDL $379,624
1995Purchase of multiple peptide synthesizer
Research Foundation of the University of Pennsylvania
Total Support $32,000
1994-1997Structural and functional analysis of complement proteins from different species
NSF MCB-9319111
Total Support $300,000
1993-1998Structural and functional analysis of C3 from different species
NIH AI 30040
Total Support $1,124,199
1992-1995Peritoneal macrophage migration in endometriosis
NIH HD 30475
(P.I.Coutifaris, C), effort 10%
Total Support for JDL $297,241
1991-2002Support Grant
University of Pennsylvania Diabetes Center
2P30-DK-19525
(P.I.Matschinsky, F), effort 10%
Total Support for JDL $480,625
1991-1994Structural and functional analysis of chicken and lamprey C3
NSF DCB-9018751
Total Support $300,000
1991-1992Research Grant
Research Foundation of the University of Pennsylvania
URF-3-71696
Total Support $12,000
1990-1991Structural analysis of C3d/EBV-CR2 interactions
American Cancer Society
IN-135K
Total Support $10,000
1989-2001Support Grant
University of Pennsylvania Cancer Center
5P30-CA-16520 (P.I.Glick, J), effort 10%
Total Support for JDL $710,000
1984-1987Research Grant
NIH 1R01-AI21014
Total Support $320,000
1982-1984New Investigator Award
NIH IR23-AI-18546
Total Support $180,000
1982Research Grant
American Cancer Society IM-308
Total Support $140,000

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Address

Department of Pathology & Laboratory Medicine
401 Stellar-Chance labs
422 Curie Boulevard
Philadelphia, PA 19104-6100

Contact Information

Tel: (215)-746-5765 (Office)
Tel: (215)-746-5762 (Lab Administrator)
Fax: (215)-573-8738
Email: lambris@upenn.edu

Publication Metrics

(Google Scholar)
Citations > 64,526
h-index > 133
i10-index > 482

Nothing can be attained without effort.

Musonius

There are two sides to every question.

Protagoras

It is necessary to strive.

Euripides

No progress is made without exertion.

Sophocles

Even the wisest of wise men makes mistakes.

Aeschylus

Happiness resides not in posessions and not in gold; the feeling of happiness dwells in the soul.

Democritus

Nothing is more important than hard work.

Antiphanes

Skillful pilots gain their reputation from storms and tempest.

Epicurus

Effort is said to be the father of fame.

Euripides

One that desires to excel should endeavor in those things that are in themselves most excellent.

Epictetus

The art of living well and the art of dying well are one.

Epicurus

The good should be measured by quality not quantity.

Aesop

Don’t render judgment before you hear both sides.

Hesiod

If someone is not taught then he can conquer neither art nor wisdom.

Democritus

To make no mistakes is not in the power of man; but from their errors and mistakes the wise and good learn wisdom for the future.

Plutarch

The one exclusive sign of thorough knowledge is the power of teaching.

Aristotle

A ship is safer with three anchors than one.

Euripides

Much learning does not teach understanding.

Heraclitus

No good comes of idleness.

Sophocles

Work is not shameful; it is shameful not to work.

Hesiod

There is no human activity without obstacles.

Simonides

The beginning is more than half of the whole, and when one has begun many of the things one seeks have already become known.

Aristotle

One hand washes the other.

Epicharmus

All things can be achieved through industry and effort.

Menander

It is possible to provide security against other ills, but as far as death is concerned, we men all live in a city without walls.

Epicurus

The mind is not a vessel to be filled but a fire to be kindled.

Plutarch

Not to unlearn what you have learned is the most necessary kind of learning.

Antisthenes

The race will not wait for the tardy athlete.

Fragments of the tragic poets

Glory is not won through easy struggles.

Sophocles

Good things are accomplished through learning and hard work.

Democritus

A good decision is based on knowledge and not on numbers.

Plato

Whenever the art of medicine is loved, there is also a love of humanity.

Hippocrates

Work above all brings light into our lives.

Pindar

Nothing great can be achieved without great risk.

Herodotus

Nature is used to hiding herself.

Heraclitus

Neither skill nor wisdom can be achieved without knowledge.

Democritus