Issued and Pending Patents

Compstatin Analogs With Increased Solubility And Improved Pharmacokinetic Properties. Type: Application. Issued: January 28, 2020 (US Patent #10,800,812. Inventors: John D. Lambris.
Modified Compstatin with Improved Stability and Binding Properties (Thioether). Type: Application. Issued: April 24, 2014. Inventors: J.D. Lambris, and W. van der Donk. 
Complement-Mediated Thrombophilic Assay. (US Patent #8563259). Issued: October 22, 2013. Inventors: J.D. Lambris and K. Ritis. 
Compstatin Analogs with Improved Pharmacokinetic Properties. Type: Application. Issued: June 11, 2015. Inventors: J.D. Lambris, H. Qu, and D. Ricklin. 
Complement Inhibitors as Therapeutic Agents for Treatment of Cancer. Type: Application. Issued: February 24, 2011. Inventors: J.D. Lambris and M. Markiewski. 
Complement Inhibitors for Treatment of Injury from Intracebral Hemorrhage. Type: Application. Issued: October 20, 2011. Inventors: J.D. Lambris and S.E. Connolly. 
Compositions and Methods for Inhibiting Inducible T Cell Kinase (ITK) and Treating Asthma and Bronchial Inflammations. Type: Application. Issued: November 11, 2010. Inventors: K. Tsoukas and J.D. Lambris. 
Compstatin Analogs with Improved Activity. Type: Grant (US Patent #8883413). Issued: November 11, 2014. Inventors: J.D. Lambris. 
Compstatin Analogs with Improved Activity. Type: Application. Issued: June 11, 2015. Inventors: J.D. Lambris. 
Compstatin Analogs with Improved Activity. Type: Grant (US Patent #7989589). Issued: August 2, 2011. Inventors: J.D. Lambris. 
Compstatin Analogs with Increased Solubility and Improved Pharmacokinetic Properties. Pending. Inventors: J.D. Lambris. 
Factor H Binding Peptides and Uses Thereof. Type: Grant (US Patent #8962795). Issued: February 24, 2015. Inventors: J. D. Lambris. 
Regulator of Complement Activation and Uses Thereof. Type: Grant (US Patent #9540626). Issued: January 10, 2017. Inventors: J.D. Lambris, D. Ricklin, and C.Q. Schmidt.  
Method of Inhibiting Biomaterial-Induced Procoagulant Activity Using Complement Inhibitors. Type: Grant (US Patent #8445190). Issued: May 21, 2013. Inventors: J.D. Lambris and K. Ritis. 
Method of Reducing Tissue Loss in Pancreatic Islet Cell Transplantation. Type: Application. Issued: January 13, 2011. Inventors: J.D. Lambris, O. Korsgren, and B. Nillson. 
Method of Treating Respiratory Acute Distress Syndrome. Type: Application. Issued: June 16, 2011. Inventors: J.D. Lambris, and K. Ritis. 
Methods of Treating or Preventing Periodontitis and Diseases Associated with Periodontitis. Type: Application. Issued: December 26, 2013.  Inventors: G. Hajishengallis and J.D. Lambris. 
Methods of Treating or Preventing Periodontitis and Diseases Associated with Periodontitis. Type: Application. Issued: February 7, 2013.  Inventors: G. Hajishengallis and J.D. Lambris. 
Modified Compstatin with Peptide Backbone and C-Terminal Modifications. Type: Grant (US Patent #8946145). Issued: July 23, 2015. Inventors: J.D. Lambris and H. Qu. 
Peptides for Inhibition of Herpes Simplex Virus Entry. Type: Grant (US Patent #6699481). Issued: March 2, 2004. Inventors: J.D. Lambris, M.R. Sarrias, G.H. Cohen, P.G. Spear, and R.I. Mongomery. 
Peptides for Inhibition of Herpes Simplex Virus Entry. Type: Application. Issued: December 23, 2004. Inventors: J.D. Lambris, M.R. Sarrias, G.H. Cohen, R.J. Eisenberg, P.G. Spear, and R.I. Montgomery. 
Peptides which Inhibit Complement Activation. Type: Grant (US Patent #6319897). Issued: November 20, 2001. Inventors: J.D. Lambris and A. Sahu. 
Potent Compstatin Analogs. Type: Grant (US Patent #7888323). Issued: February 15, 2011. Inventors: J.D. Lambris and M. Katragadda. 
Regulator of Complement Activation and Uses Thereof. Type: Application. Issued: April 23, 2015. Inventors: J.D. Lambris, C. Schmidt, and D. Ricklin. 
Secreted Staphylococcus Aureus Proteins and Peptides for Use in Inhibiting Activation of the Complement System. Type: Application. Issued: February 24, 2011. Inventors: J.D. Lambris and B.V. Geisbrecht. 
Structure of Compstatin-C3 Complex and Use for Rational Drug Design. Type: Grant (US Patent #8442776). Issued: May 14, 2013. Inventors: J.D. Lambris, B.J.C. Janssen, and P. Gros. 
Treatment of Colon Cancer Using Complement Inhibitors. Type: Application. Issued: August 7, 2014. Inventors: J.D. Lambris, J. Nadeau, S. Doerner, and N. D. Berger.
Treatment of Sepsis Using Complement Inhibitors. Type: Application. Issued: February 28, 2013. Inventors: J.D. Lambris, F. B. Taylor, F. Lupu, and G. Kinasewitz. 

Click here for Published Patents and Applications.

Social Links

Address

Department of Pathology & Laboratory Medicine
401 Stellar-Chance labs
422 Curie Boulevard
Philadelphia, PA 19104-6100

Contact Information

Tel: (215)-746-5765 (Office)
Tel: (215)-746-5762 (Lab Administrator)
Fax: (215)-573-8738
Email: lambris@upenn.edu

Publication Metrics

(Google Scholar)
Citations > 64,526
h-index > 133
i10-index > 482

Nothing great can be achieved without great risk.

Herodotus

There are two sides to every question.

Protagoras

Not to unlearn what you have learned is the most necessary kind of learning.

Antisthenes

The mind is not a vessel to be filled but a fire to be kindled.

Plutarch

Effort is said to be the father of fame.

Euripides

There is no human activity without obstacles.

Simonides

Work is not shameful; it is shameful not to work.

Hesiod

No good comes of idleness.

Sophocles

One that desires to excel should endeavor in those things that are in themselves most excellent.

Epictetus

It is possible to provide security against other ills, but as far as death is concerned, we men all live in a city without walls.

Epicurus

The art of living well and the art of dying well are one.

Epicurus

To make no mistakes is not in the power of man; but from their errors and mistakes the wise and good learn wisdom for the future.

Plutarch

Neither skill nor wisdom can be achieved without knowledge.

Democritus

Work above all brings light into our lives.

Pindar

No progress is made without exertion.

Sophocles

Whenever the art of medicine is loved, there is also a love of humanity.

Hippocrates

Glory is not won through easy struggles.

Sophocles

Happiness resides not in posessions and not in gold; the feeling of happiness dwells in the soul.

Democritus

The good should be measured by quality not quantity.

Aesop

If someone is not taught then he can conquer neither art nor wisdom.

Democritus

Even the wisest of wise men makes mistakes.

Aeschylus

A ship is safer with three anchors than one.

Euripides

The race will not wait for the tardy athlete.

Fragments of the tragic poets

It is necessary to strive.

Euripides

All things can be achieved through industry and effort.

Menander

Much learning does not teach understanding.

Heraclitus

One hand washes the other.

Epicharmus

Skillful pilots gain their reputation from storms and tempest.

Epicurus

Nothing can be attained without effort.

Musonius

Nature is used to hiding herself.

Heraclitus

The beginning is more than half of the whole, and when one has begun many of the things one seeks have already become known.

Aristotle

Don’t render judgment before you hear both sides.

Hesiod

Good things are accomplished through learning and hard work.

Democritus

Nothing is more important than hard work.

Antiphanes

A good decision is based on knowledge and not on numbers.

Plato

The one exclusive sign of thorough knowledge is the power of teaching.

Aristotle